Epigenome-Wide Meta-Analysis of Prenatal Maternal Stressful Life Events and Newborn DNA Methylation

Details

• Personal Author:
  Bakulski KM ; Binder EB ; Brunst KJ ; Campbell ML ; Caramaschi D ; Cecil CAM ; Colicino E ; Cortés Hidalgo AP ; Cruceanu C ; Czamara D ; Dieckmann L ; Dou J ; Felix JF ; Frank J ; Håberg SE ; Herberth G ; Hoang TT ; Houtepen LC ; Hüls A ; Koen N ; Kotsakis Ruehlmann A ; Lahti J ; London SJ ; Magnus MC ; Mancano G ; Mulder RH ; Page CM ; Räikkönen K ; Röder S ; Sammallahti S ; Schmidt RJ ; Send TS ; Sharp G ; Stein DJ ; Streit F ; Tuhkanen J ; Witt SH ; Wright R ; Zar HJ ; Zenclussen AC ; Zhang Y ; Zillich L
• Description:
  Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. Biological mechanisms underlying these associations are largely unknown, but DNA methylation likely plays a role. This meta-analysis included twelve non-overlapping cohorts from ten independent longitudinal studies (N = 5,496) within the international Pregnancy and Childhood Epigenetics consortium to examine maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of cg26579032 in ALKBH3. Stressor-specific domains of conflict with family/friends, abuse (physical, sexual, and emotional), and death of a close friend/relative were also associated with differential methylation of CpGs in APTX, MyD88, and both UHRF1 and SDCCAG8, respectively; these genes are implicated in neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. Thus, differences in DNA methylation at these loci may provide novel insights into potential mechanisms of neurodevelopment in offspring. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Epidemiology Genetics Occupational Health Pregnancy Safety
• Keywords:
  Cohort Studies DNA Damage Genomics Longitudinal Study Prenatal Exposure Stress
• ISSN:
  1359-4184
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; Michigan ; New York ; North Carolina ; Ohio ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  28
• Issue:
  12
• NIOSHTIC Number:
  nn:20070607
• Citation:
  Mol Psychiatry 2023 Dec; 28(12):5090-5100
• Contact Point Address:
  Kelly J. Brunst, University of Cincinnati College of Medicine, Department of Environmental and Public Health Sciences, Cincinnati, OH, USA
• Email:
  Kelly.Brunst@uc.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Molecular Psychiatry
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:72390222669b9fae20848c2865f2ab06e8a81836cee5ab6b69bbc3a863f53c2cd4cdc7919e461893353f45b4d878cb90fa88daae4731ccaeecdb2547b55b3df3
• Download URL:
  https://stacks.cdc.gov/view/cdc/208786/cdc_208786_DS1.pdf
• File Type:
  [PDF - 1.69 MB ]