Nitro-PAH Exposures of Occupationally-Exposed Traffic Workers and Associated Urinary 1-Nitropyrene Metabolite Concentrations

Details

• Personal Author:
  Cassidy B ; Hayakawa K ; Kameda T ; Miller-Schulze JP ; Naeher L ; Paulsen M ; Simpson CD ; Toriba A ; Villalobos MA
• Description:
  The assessment of occupational exposure to diesel exhaust (DE) is important from an epidemiological perspective. Urinary biomarkers of exposure have been proposed as a novel approach for measuring exposure to DE. In this study, we measured the concentrations of two urinary metabolites of 1-nitropyrene (1NP), a nitrated polycyclic aromatic hydrocarbon that has been suggested as a molecular marker of diesel particulate matter. These two metabolites, 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were determined in urine samples (10 mL) from a small group of workers who were occupationally-exposed to vehicle exhaust in Trujillo, Peru, before and after their workshifts. Workshift exposures to 1NP, as well as PM2.5, 2-nitropyrene and 2-nitrofluoranthene, were also measured. Exposures to 1NP were similar in all studied workers, averaging 105 +/- 57.9 pg/m3 (+/- standard deviation). Median urinary concentrations of the average of the pre- and post-exposure samples for 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were found to be 3.9 and 2.3 pg metabolite/mg creatinine, respectively in the group of occupationally-exposed subjects (n = 17) studied. A direct relationship between workshift exposure to 1NP and urinary 1NP metabolites concentrations was not observed. However, the 1NP exposures and the creatinine-corrected urinary concentrations of the hydroxynitropyrene metabolites in these Peruvian traffic workers were similar to occupationally-exposed taxi drivers in Shenyang, China, and were higher than biomarker levels in office workers from Trujillo without occupational exposure to vehicle exhaust. This study provides further evidence that urinary metabolites of 1NP are associated with exposure to DE and may serve as a useful exposure biomarker. [Description provided by NIOSH]
• Subjects:
  Automobiles Biomarkers Hydrocarbons Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Safety Transportation
• Keywords:
  1-Nitropyrene Author Keywords: Urinary Biomarkers Diesel Exhaust Diesel Particulate Matter Drivers Exposure Assessment Occupational Exposure Polycyclic Aromatic Hydrocarbons Transportation Workers
• ISSN:
  1001-0742
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; OSHA Region 10 ; OSHA Region 4 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  213-221
• Volume:
  49
• NIOSHTIC Number:
  nn:20063728
• Citation:
  J Environ Sci (China) 2016 Nov; 49:213-221
• Contact Point Address:
  Christopher D. Simpson, Department of Environmental and Occupational Health Sciences, University of Washington, WA 98195, Seattle, USA
• Email:
  simpson1@uw.edu
• CAS Registry Number:
  1-Nitropyrene (CAS RN 5522-43-0)
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Environmental Sciences (China)
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ba83275bb52b60a4ed16c0815754b6cc99fbf9b53176b05b2ace8741b57a48197589679c7a00096c54978b1d09f7cfef14b166a8edb4eee1e0b63117b3cd05a3
• Download URL:
  https://stacks.cdc.gov/view/cdc/222289/cdc_222289_DS1.pdf
• File Type:
  [PDF - 304.00 KB ]