Long Term Exposure to NO2 and Diabetes Incidence in the Black Women’s Health Study

Details

• Personal Author:
  Brook RD ; Burnett RT ; Coogan PF ; Jerrett M ; Marshall JD ; Palmer JR ; Rosenberg L ; Seto E ; White LF ; Yu J
• Description:
  While laboratory studies show that air pollutants can potentiate insulin resistance, the epidemiologic evidence regarding the association of air pollution with diabetes incidence is conflicting. The purpose of the present study was to assess the association of the traffic-related nitrogen dioxide (NO2) with the incidence of diabetes in a longitudinal cohort study of African American women. We used Cox proportional hazards models to calculate hazard ratios and 95% confidence intervals (CI) for diabetes associated with exposure to NO2 among 43,003 participants in the Black Women's Health Study (BWHS). Pollutant levels at participant residential locations were estimated with 1) a land use regression model for participants living in 56 metropolitan areas, and 2) a dispersion model for participants living in 27 of the cities. From 1995 to 2011, 4387 cases of diabetes occurred. The hazard ratios per interquartile range of NO2 (9.7 ppb), adjusted for age, metropolitan area, education, vigorous exercise, body mass index, smoking, and diet, were 0.96 (95% CI 0.88-1.06) using the land use regression model estimates and 0.94 (95% CI 0.80, 1.10) using the dispersion model estimates. The present results do not support the hypothesis that exposure to NO2 contributes to diabetes incidence in African American women. [Description provided by NIOSH]
• Subjects:
  Air Pollution Blood Cohort Studies Epidemiology Hematologic Diseases Occupational Health Particulate Matter Safety Women
• Keywords:
  Air Pollution Author Keywords: African American Blood Sugar Disorders Cohort Studies Cohort Study Diabetes Health Effects Incidence Particulates
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; Michigan ; Minnesota ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 5 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  360-366
• Volume:
  148
• NIOSHTIC Number:
  nn:20063696
• Citation:
  Environ Res 2016 Jul; 148:360-366
• Contact Point Address:
  Patricia F. Coogan, Slone Epidemiology Center at Boston University, 1010 Commonwealth Ave., Boston, MA 02215, USA
• Email:
  pcoogan@bu.edu
• CAS Registry Number:
  Nitrogen dioxide (CAS RN 10102-44-0)
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8f8bf951bf346eb207835cd53dd0b13f999311be5697cf40a7a666484989b8b9679da4caf2f75f4c01bc0e1f98c0035e4858c7d5cc370d3ec9a6844e7ac3acce
• Download URL:
  https://stacks.cdc.gov/view/cdc/222257/cdc_222257_DS1.pdf
• File Type:
  [PDF - 339.74 KB ]