Candidate Gene DNA Methylation Associations with Breast Cancer Characteristics and Tumor Progression

Details

• Personal Author:
  Argos M ; Chen HY ; Erdal S ; Gann PH ; Kresovich JK ; Rauscher GH
• Description:
  Aim: We examined methylation patterns with aggressive tumor phenotypes and investigated demographic, socioeconomic and reproductive predictors of gene methylation. Materials & methods: Pyrosequencing quantified methylation of BRCA1, EGFR, GSTM2, RASSF1, TFF1 and Sat 2. We used quantile regression models to calculate adjusted median methylation values by estrogen and progesterone receptor (ER/PR) status. Bivariate associations between participant characteristics and methylation were examined. Results: Higher percent methylation of GSTM2 was observed in ER/PR-negative compared with ER/PR-positive tumors in ductal carcinoma in situ (14 vs 2%) and invasive (35 vs 3%) tissue components. Trends in aberrant GSTM2 methylation across tissue components were stronger among ER/PR-negative tumors (p-interaction <0.001). Black women were more likely to have ER/PR-negative tumors (p = 0.01) and show hypermethylation of GSTM2 compared with other women (p = 0.05). Conclusion: GSTM2 promoter hypermethylation may serve as a potential biomarker of aggressive tumor development and a mechanism for ER/PR-negative tumor progression. [Description provided by NIOSH]
• Subjects:
  Biomarkers Demography Epidemiology Healthcare Disparities Occupational Health Safety
• Keywords:
  Author Keywords: Breast Cancer Breast Cancer Breast Cancer Disparities Demographic Characteristics DNA Methylation Estrogen/Progesterone Receptor Gene Expression Genomics GSTM2 Health Disparities Socioeconomics Tumor Progression

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• ISSN:
  1750-1911
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  367-378
• Volume:
  10
• Issue:
  4
• NIOSHTIC Number:
  nn:20063616
• Citation:
  Epigenomics 2018 Apr; 10(4):367-378
• Contact Point Address:
  Jacob K Kresovich, Division of Epidemiology & Biostatistics, University of Illinois at Chicago School of Public Health, Chicago, IL 60612, USA
• Email:
  jacob.kresovich@nih.gov
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Epigenomics
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:75a043c66980ba74c82950dedd44594da56eaa6d85f2f8fe87596c88861ccd32781783e888527d516a62a5a69a457e705fba99a8bf1b3f1272b9b04672306f28
• Download URL:
  https://stacks.cdc.gov/view/cdc/222189/cdc_222189_DS1.pdf
• File Type:
  [PDF - 828.10 KB ]