An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors.

Details

• Personal Author:
  Bonanni B ; Cardenas A ; Chung FF-L ; Cuenin C ; Hartman SJ ; Herceg Z ; Hubbard AE ; Johansson H ; Novoloaca A ; Nwanaji-Enwerem JC ; Sears DD ; Smith MT ; Van der Laan L
• Description:
  Metformin and weight loss relationships with epigenetic age measures-biological aging biomarkers-remain understudied. We performed a post-hoc analysis of a randomized controlled trial among overweight/obese breast cancer survivors (N = 192) assigned to metformin, placebo, weight loss with metformin, or weight loss with placebo interventions for 6 months. Epigenetic age was correlated with chronological age (r = 0.20-0.86; P < 0.005). However, no significant epigenetic aging associations were observed by intervention arms. Consistent with published reports in non-cancer patients, 6 months of metformin therapy may be inadequate to observe expected epigenetic age deceleration. Longer duration studies are needed to better characterize these relationships. [Description provided by NIOSH]
• Subjects:
  Biomarkers Body Weight Epidemiology Occupational Health Safety
• Keywords:
  Author Keywords: RCT; DNA Methylation Age; Biomarkers; GrimAge; PhenoAge Epidemiology; Body Weight; Biomarkers; Obesity; Breast Cancer; Cancer Survivors; Intervention; Weight Factors;
• ISSN:
  1868-7083
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  1
• NIOSHTIC Number:
  nn:20065525
• Citation:
  Clin Epigenetics 2021 Dec; 13(1):224
• Contact Point Address:
  Jamaji C. Nwanaji-Enwerem, Department of Emergency Medicine, Gangarosa Department of Environmental Health, Emory University School of Medicine, Emory Rollins School of Public Health, 1518 Clifton Rd. NE, Atlanta, GA, 30322, USA
• Email:
  jnwanaj@emory.edu
• CAS Registry Number:
  6Strychnine (CAS RN 57-24-9)
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Clinical Epigenetics
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ee88d4b5b97c6558332d55daf5f3ccdfc5f30fa5ab8b37d57abe9ece4cca63c1828abc95d2368e797b4f1b60853891733e111e9978a5f851eba86fe8203d7314
• Download URL:
  https://stacks.cdc.gov/view/cdc/248560/cdc_248560_DS1.pdf
• File Type:
  [PDF - 918.51 KB ]