Comparison of Serum Versus Lipid-Adjusted Concentrations of Organochlorine Pesticides in the Evaluation of Associations with Exposure Variables and Health Effects in a Community-Based Environmental Health Study

Details

• Personal Author:
  Campbell RS
• Description:
  Adipose tissue concentrations of organochlorine pesticides are difficult to measure; therefore, serum concentrations are used as a proxy. Lipid-adjustment of serum concentrations has been proposed as a more accurate indicator of adipose concentrations. This study examined clinical data from 500 participants in the Del Amo/Montrose Community Environmental Health Program to assess correlations between serum and lipid-adjusted concentrations of organochlorine pesticides. The study also analyzed associations between these pesticides and demographic and exposure variables, and with health outcomes to determine whether the patterns of association were affected by lipid-adjustment or were different among the pesticides. General linear models and least squares linear regression were used to analyze exposure variable associations, while logistic regression was used to analyze dichotomous health outcomes. Adjusting for lipids did not substantially change the patterns of associations for pesticides in the analyses of exposure variables or health outcomes. Pesticide concentrations were associated with increasing age and higher educational level, but the trends were weaker with lipid adjustment. DDT, hexachlorobenzene, and hexachlorocyclohexane concentrations were associated with prior residence in Mexico or Latin America, but other pesticides were not. Aldrin/dieldrin, chlordane, and DDT were associated with local egg consumption. Heptachlor and hexachlorocyclohexane were associated with fish consumption. Some health outcomes were associated with pesticide concentrations, but in no general pattern. Overall, lipid adjustment did not materially affect associations between organochlorine pesticide concentrations and exposure variables or health outcomes. Associations for some pesticides were consistent with expected routes of exposure and suggest the possibility of excess past environmental exposures. [Description provided by NIOSH]
• Subjects:
  Demography Environmental Exposure Insecticides Lipids Occupational Health Safety
• Keywords:
  Biological Monitoring Demographic Characteristics Environmental Exposure Environmental Health Monitoring Health Effects Organochlorine Compounds Pesticides And Agricultural Chemicals
• Publisher:
  University of California Irvine
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Thesis
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-102
• NIOSHTIC Number:
  nn:20058680
• Citation:
  Irvine, CA: University of California Irvine, 2006 Jun; :1-102
• Federal Fiscal Year:
  2006
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Comparison of serum versus lipid-adjusted concentrations of organochlorine pesticides in the evaluation of associations with exposure variables and health effects in a community-based environmental health study
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:90dc5e8e62052c4a1505b3afc5129bd25398f1e81b7907116f5dbdf163c3873648c769f115de4541731b55d05791ac4e82a986ff798c4b4598d3d8f47e2e08e0
• Download URL:
  https://stacks.cdc.gov/view/cdc/221715/cdc_221715_DS1.pdf
• File Type:
  [PDF - 3.46 MB ]