Diacetyl-Induced Lung Disease

Details

• Personal Author:
  Boomus C ; Harber P ; Saechao K
• Description:
  Diacetyl is a diketone flavouring agent that is commonly employed for buttery taste as well as other purposes. Industrial exposure to flavouring agents, particularly diacetyl, has recently been associated with bronchiolitis obliterans, a severe respiratory illness producing fibrosis and obstruction of the small airways. This has been most commonly reported in the microwave popcorn production industry, but it has occurred elsewhere. In addition to bronchiolitis obliterans, spirometry abnormalities (fixed airflow obstruction) and respiratory symptoms have been associated with exposure. A direct effect on the respiratory epithelium with the disorganised fibrotic repair appears most likely as the underlying mechanism. Current data suggest that diacetyl is the agent responsible, although it is possible that diacetyl is simply a marker for another causative agent. [Description provided by NIOSH]
• Subjects:
  Diacetyl Flavoring Agents Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Toxicology
• Keywords:
  Flavorings Health Effects Lung Disease Lung Fibrosis Popcorn Flavorings Respiratory Diseases Respiratory Function Tests
• ISSN:
  1176-2551
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  261-272
• Volume:
  25
• Issue:
  4
• NIOSHTIC Number:
  nn:20058523
• Citation:
  Toxicol Rev 2006 Dec; 25(4):261-272
• CAS Registry Number:
  Butanedione (CAS RN 431-03-8)
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Toxicological Reviews
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fafef98914f809aaae87b8939a8ce8b6fb4a19b28365ebf2abd0c11ab6bf19e8be0ea4a54b96204aa8d4a4130e2562d321cec543478b2a3e490aadab81205e04
• Download URL:
  https://stacks.cdc.gov/view/cdc/221598/cdc_221598_DS1.pdf
• File Type:
  [PDF - 821.22 KB ]