Aluminum and Copper in Drinking Water Enhance Inflammatory or Oxidative Events Specifically in the Brain

Details

• Personal Author:
  Becaria A ; Bondy SC ; Campbell A ; Chen D ; Hamadeh A ; Lahiri DK ; Li H ; Taylor R
• Description:
  Inflammatory and oxidative events are up-regulated in the brain of AD patients. It has been reported that in animal models of AD, exposure to aluminum (Al) or copper (Cu) enhanced oxidative events and accumulation of amyloid beta (AB) peptides. The present study was designed to evaluate the effect of a 3-month exposure of mice to copper sulfate (8 uM), aluminum lactate (10 or 100 uM), or a combination of the salts. Results suggest that although Al or Cu may independently initiate inflammatory or oxidative events, they may function cooperatively to increase APP levels. [Description provided by NIOSH]
• Subjects:
  Aluminum Compounds Animals Copper Enzymes Occupational Health Oxidants Safety
• Keywords:
  Aluminum Aluminum Compounds Alzheimer's Disease Amyloid Beta Animal Studies Author Keywords: Aluminum Copper Compounds Enzymatic Effects Enzyme Activity Neuroinflammation Neurological Diseases Oxidative Processes Oxidative Stress

  More +
• ISSN:
  0165-5728
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Indiana ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  16-23
• Volume:
  176
• Issue:
  1
• NIOSHTIC Number:
  nn:20058436
• Citation:
  J Neuroimmunol 2006 Jul; 176(1-2):16-23
• Contact Point Address:
  Arezoo Campbell, Department of Community and Environmental Medicine, Center for Occupational and Environmental Health Sciences, University of California, Irvine, Irvine, CA 92697-1825, USA
• Email:
  aghadimi@uci.edu
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5) ; Copper (CAS RN 7440-50-8)
• Federal Fiscal Year:
  2006
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Neuroimmunology
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7d40a705c5f9a1c509ab62eb23fff60eed42f3f71bc4c94b8f77f69902faf09fb6218f31cb7cef1f36f59f7fafe53ccdd8429eaae00acc106b098dbbdaed094d
• Download URL:
  https://stacks.cdc.gov/view/cdc/221528/cdc_221528_DS1.pdf
• File Type:
  [PDF - 214.28 KB ]