Aluminum and Copper Interact in the Promotion of Oxidative but Not Inflammatory Events: Implications for Alzheimer’s Disease

Details

• Personal Author:
  Becaria A ; Bondy SC ; Campbell A
• Description:
  The etiology of Alzheimer's Disease (AD) is multifactorial. It has been suggested that transition metals such as copper (Cu) and iron (Fe) as well as aluminum (Al) may be involved in the pathogenesis of the disorder. While Cu and Fe are redox-active, Al only exists in the trivalent form and is redox-inert. We previously demonstrated that Al exposure causes an increase in inflammatory parameters in human glioblastoma T98G cells. In the present study we further demonstrate that co-exposure with Cu exacerbates the oxidative but not inflammatory effects of Al in this cell line. While Cu-induced reactive oxygen species (ROS) production was greatly enhanced in the presence of Al, TNF-a secretion induced by either metal was not further potentiated by simultaneous exposure to Al and Cu. Furthermore, exposure to both metals reduced the individual Al and Cu-induced activation of the immune-related transcription factor NF-kB. Therefore, while synergistic interaction between the two metals increases oxidative events, this does not lead to potentiation of Al-induced inflammation. Thus the ability of aluminum to promote inflammatory processes does not depend on an increase ROS production induced by interaction with transition metals. [Description provided by NIOSH]
• Subjects:
  Aluminum Compounds Copper Ferrous Compounds Immune System Occupational Health Oxidants Safety
• Keywords:
  Aluminum Author Keywords: Neuroinflammation Brain Disorders Cytokines Immune Reaction Iron NF-kB Oxidative Processes Oxidative Stress Pathogenesis Transition Metals

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• ISSN:
  1387-2877
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  31-38
• Volume:
  5
• Issue:
  1
• NIOSHTIC Number:
  nn:20058011
• Citation:
  J Alzheimers Dis 2003 Feb; 5(1):31-38
• Contact Point Address:
  A. Becaria, Department of Community & Environmental Medicine. University of California, Irvine, Irvine, California 92697-1820. USA
• Email:
  abecaria@uci.edu
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5) ; Copper (CAS RN 7440-50-8) ; Iron (CAS RN 7439-89-6)
• Federal Fiscal Year:
  2003
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  True
• Start Date:
  19990701
• Source Full Name:
  Journal of Alzheimer's Disease
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c4cfa58365e5474a3eb90972851cc72202c5a0330f17b423c9d9073eeb8f9dffc4ef578eabd4c8e72a53d666aa3b0346577987f0384ad1f208cec1d63756becc
• Download URL:
  https://stacks.cdc.gov/view/cdc/215204/cdc_215204_DS1.pdf
• File Type:
  [PDF - 302.64 KB ]