Parallel Changes in Gene Expression in Aged Human and Mouse Cortex

Details

• Personal Author:
  Bondy SC ; Sharman EH ; Sharman KG
• Description:
  The intensity of expression of over 20,000 genes and expressed sequence tags within the cerebral cortex has previously been described for both the human and mouse genomes. In both these species, the degree of expression of a relatively limited number of cortical genes, around 300, is significantly altered during senescence. The extent of similarity between age-related alterations of levels of specific mRNAs in either species has been compared. There is a significant correlation between species in those genes whose expression changes markedly in either direction with aging. This parallel serves to validate the use of mouse strains to study general age-related genetic events associated with aging. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Genetics Occupational Health Safety
• Keywords:
  Age Factors Author Keywords: Aging Gene Expression Gene Profile Genes
• ISSN:
  0304-3940
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  4-8
• Volume:
  390
• Issue:
  1
• NIOSHTIC Number:
  nn:20058435
• Citation:
  Neurosci Lett 2005 Dec; 390(1):4-8
• Contact Point Address:
  Edward H. Sharman, Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, 19772 Jamboree, Irvine, CA 92697-1825, USA
• Email:
  esharman@uci.edu
• Federal Fiscal Year:
  2006
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Neuroscience Letters
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e1dfa3d42449c58e95d9ef985c59c62f220ceb7d5bfcca95d5a3dcef6896a6fe482d08db594bc3fff55d542affa5729bd338de78ad54792af777a077fedde1c6
• Download URL:
  https://stacks.cdc.gov/view/cdc/221527/cdc_221527_DS1.pdf
• File Type:
  [PDF - 64.91 KB ]