Nested Case-Control Study of Occupational Physical Activity and Prostate Cancer Among Workers Using a Job Exposure Matrix

Details

• Personal Author:
  Kennedy N ; Krishnadasan A ; Morgenstern H ; Ritz B ; Zhao Y
• Description:
  Objective: We conducted a nested case-control study of 362 cases diagnosed between 1 January 1988 and 31 December 1999, and 1,805 matched controls to examine the association between occupational physical activity and prostate-cancer incidence among workers at a nuclear and rocket engine-testing facility in Southern California. Methods: We obtained cancer incidence data from the California Cancer Registry and seven other state cancer registries. Data from company records were used to construct a job exposure matrix (JEM) for occupational physical activity during employment. Conditional logistic regression was used to estimate associations. Results: With adjustment for occupational confounders, including socioeconomic status and trichloroethylene (TCE) exposure, high activity levels at work were inversely associated with prostate-cancer incidence among aerospace workers (odds ratio [OR] = 0.55; 95% CI = 0.32-0.95), but not among radiation workers (OR = 0.95; 95% CI = 0.43-2.1). Conclusions: Our results suggest that adult men who are more continually active at work may have a decreased risk of prostate cancer. [Description provided by NIOSH]
• Subjects:
  Men Occupational Health Safety
• Keywords:
  Activity Levels Author Keywords: Occupational Physical Activity JEM Job Exposure Matrix Nested Case-control Study Occupations Physical Exercise Prostate Cancer
• ISSN:
  0957-5243
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Michigan ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  107-114
• Volume:
  19
• Issue:
  1
• NIOSHTIC Number:
  nn:20058367
• Citation:
  Cancer Causes Control 2008 Feb; 19(1):107-114
• Contact Point Address:
  Anusha Krishnadasan, Department of Emergency Medicine, Olive View-UCLA, Medical Center, 14445 Olive View Drive, North Annex Bldg., Rm 105, Sylmar, CA 91342, USA
• Email:
  akrishna@ucla.edu
• Federal Fiscal Year:
  2008
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Cancer Causes and Control
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ed52caa93b5537f8c5ebeb73b17a8411391dde667efef4586b8685c2a3094769d06a9c0b9b3a6830f706cca3ade5d6d87a1a93bd921e3678682c1a15a07c87eb
• Download URL:
  https://stacks.cdc.gov/view/cdc/221482/cdc_221482_DS1.pdf
• File Type:
  [PDF - 158.58 KB ]