Nested Case-Control Study of Occupational Chemical Exposures and Prostate Cancer in Aerospace and Radiation Workers

Details

• Personal Author:
  Kennedy N ; Krishnadasan A ; Morgenstern H ; Ritz B ; Zhao Y
• Description:
  Background: To date, little is known about the potential contributions of occupational exposure to chemicals to the etiology of prostate cancer. Previous studies examining associations suffered from limitations including the reliance on mortality data and inadequate exposure assessment. Methods: We conducted a nested case-control study of 362 cases and 1,805 matched controls to examine the association between occupational chemical exposures and prostate cancer incidence. Workers were employed between 1950 and 1992 at a nuclear energy and rocket engine-testing facility in Southern California. We obtained cancer-incidence data from the California Cancer Registry and seven other state cancer registries. Data from company records were used to construct a job exposure matrix (JEM) for occupational exposures to hydrazine, trichloroethylene (TCE), polycyclic aromatic hydrocarbons (PAHs), benzene and mineral oil. Associations between chemical exposures and prostate cancer incidence were assessed in conditional logistic regression models. Results: With adjustment for occupational confounders, including socioeconomic status, occupational physical activity, and exposure to the other chemicals evaluated, the odds ratio for low/moderate TCE exposure was 1.3; 95%CI = 0.8 to 2.1, and for high TCE exposure was 2.1; 95%CI = 1.2 to 3.9. Furthermore, we noted a positive trend between increasing levels of TCE exposure and prostate cancer (P-value for trend = 0.02). Conclusion: Our results suggest that high levels of TCE exposure are associated with prostate cancer among workers in our study population. [Description provided by NIOSH]
• Subjects:
  Hydrocarbons Men Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Safety Trichloroethylene
• Keywords:
  Aerospace Workers Author Keywords: Occupational Chemical Exposure Chemicals Hydrazine JEM Job Exposure Matrix Nested Case-control Study Occupational Exposure Polycyclic Aromatic Hydrocarbons Prostate Cancer Radiation Facilities

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Michigan ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  383-390
• Volume:
  50
• Issue:
  5
• NIOSHTIC Number:
  nn:20058368
• Citation:
  Am J Ind Med 2007 May; 50(5):383-390
• Contact Point Address:
  Anusha Krishnadasan, Department of Emergency Medicine, Olive View-UCLA, Medical Center, 14445 Olive View Drive, North Annex Bldg. Rm 105, Sylmar, CA 91342
• Email:
  akrishna@ucla.edu
• CAS Registry Number:
  Hydrazine (CAS RN 302-01-2) ; Trichloroethylene (CAS RN 79-01-6)
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0fe4c9572d30fca12044f20b9cf2050b32891fbb6dd19597a8a61a6654f53efa35e66d515c45e80417ee98078858f548c3fe49e688694317ed45ec335e0dc2df
• Download URL:
  https://stacks.cdc.gov/view/cdc/221483/cdc_221483_DS1.pdf
• File Type:
  [PDF - 107.61 KB ]