Maternal Occupational Exposure to Solvents and Gastroschisis in Offspring – National Birth Defects Prevention Study 1997–2011

Details

• Personal Author:
  Almli LM ; Arnold KE ; Bergman JEH ; Boezen HM ; de Walle HEK ; Desrosiers TA ; Kromhout H ; Reefhuis J ; Rocheleau C ; Spinder N
• Description:
  Objectives: The aim of this study was to assess the association between maternal occupational exposure to solvents and gastroschisis in offspring. Methods: We used data from the National Birth Defects Prevention Study, a large population-based case-control study of major birth defects conducted in 10 US states from 1997 to 2011. Infants with gastroschisis were ascertained by active birth defects surveillance systems. Control infants without major birth defects were selected from vital records or birth hospital records. Self-reported maternal occupational histories were collected by telephone interview. Industrial hygienists reviewed this information to estimate exposure to aromatic, chlorinated and petroleum-based solvents from 1 month before conception through the first trimester of pregnancy. Cumulative exposure to solvents was estimated for the same period accounting for estimated exposure intensity and frequency, job duration and hours worked per week. ORs and 95% CIs were estimated to assess the association between exposure to any solvents or solvent classes, and gastroschisis risk. Results: Among 879 cases and 7817 controls, the overall prevalence of periconceptional solvent exposure was 7.3% and 7.4%, respectively. Exposure to any solvent versus no exposure to solvents was not associated with gastroschisis after adjusting for maternal age (OR 1.00, 95% CI 0.75 to 1.32), nor was an association noted for solvent classes. There was no exposure-response relationship between estimated cumulative solvent exposure and gastroschisis after adjusting for maternal age. Conclusion: Our study found no association between maternal occupational solvent exposure and gastroschisis in offspring. Further research is needed to understand risk factors for gastroschisis. [Description provided by NIOSH]
• Subjects:
  Aging Environmental Exposure Occupational Health Pregnancy Risk Assessment Risk Factors Safety Solvents Women Workplace
• Keywords:
  Age Groups Birth Defects Children Exposure Levels Humans Industrial Hygienists Prenatal Exposure Risk Factors Statistical Analysis Surveillance Programs Work Environment Workers

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• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  172-178
• Volume:
  77
• Issue:
  3
• NIOSHTIC Number:
  nn:20058359
• Citation:
  Occup Environ Med 2020 Mar; 77(3):172-178
• Contact Point Address:
  Nynke Spinder, Department of Epidemiology, University Medical Center Groningen, Groningen, Netherlands
• Email:
  n.spinder@umcg.nl
• Federal Fiscal Year:
  2020
• Performing Organization:
  Battelle
• Peer Reviewed:
  True
• Start Date:
  20011001
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a0ddbc469bf14d18b979604cbf783a762b16e2d0844c54a49b92cdfaea37e05ae66f4aa342fb63ef156fd3831375ecf6c622bea4f31e8e8b1e00b47b11602db9
• Download URL:
  https://stacks.cdc.gov/view/cdc/221475/cdc_221475_DS1.pdf
• File Type:
  [PDF - 276.84 KB ]