Assessed occupational exposure to chlorinated, aromatic and Stoddard solvents during pregnancy and risk of fetal growth restriction

Details

• Personal Author:
  Correa A ; Desrosiers TA ; Lawson, Christina C. ; Meyer RE ; Olshan AF ; Stewart PA ; Waters MA
• Description:
  Objectives: Previous experimental and epidemiological research suggests that maternal exposure to some organic solvents during pregnancy may increase the risk of fetal growth restriction (FGR). We evaluated the association between expert-assessed occupational solvent exposure and risk of small for gestational age (SGA) infants in a population-based sample of women in the National Birth Defects Prevention Study. Methods: We analysed data from 2886 mothers and their infants born between 1997 and 2002. Job histories were self-reported. Probability of exposure to six chlorinated, three aromatic and one petroleum solvent was assessed by industrial hygienists. SGA was defined as birthweight<10th centile of birthweight-by-gestational age in a national reference. Logistic regression was used to estimate ORs and 95% CIs to assess the association between SGA and exposure to any solvent(s) or specific solvent classes, adjusting for maternal age and education. Results Approximately 8% of infants were SGA. Exposure: prevalence to any solvent was 10% and 8% among mothers of SGA and non-SGA infants, respectively. Among women with .50% probability of exposure, we observed elevated but imprecise associations between SGA and exposure to any solvent(s) (1.71; 0.86 to 3.40), chlorinated solvents (1.70; 0.69 to 4.01) and aromatic solvents (1.87; 0.78 to 4.50). Conclusions: This is the first population-based study in the USA to investigate the potential association between FGR and assessed maternal occupational exposure to distinct classes of organic solvents during pregnancy. The potential associations observed between SGA and exposure to chlorinated and aromatic solvents are based on small numbers and merit further investigation. [Description provided by NIOSH]
• Subjects:
  Epidemiology Occupational Health Petroleum Pregnancy Risk Assessment Risk Factors Safety Solvents Women Workplace
• Keywords:
  Exposure-limits Humans Industrial-hygienists Organic-solvents Petroleum-products Prenatal-exposure Risk-factors Statistical-analysis Work-environment Workers
• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  72
• Issue:
  8
• NIOSHTIC Number:
  nn:20046332
• Citation:
  Occup Environ Med 2015 Aug; 72(8):587-593
• Contact Point Address:
  Dr. Tania A Desrosiers, Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, McGavran-Greenberg Hall, CB 7435, Chapel Hill, NC 27599
• Email:
  ta_desrosiers@unc.edu
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20081130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a96170e705160030c69d861c318288a704a8118bbec0c14d56ada54956082d03389517852a141786e3ac02dbb7cc1facbe0a88777f89219e171f9f86ac37699c
• Download URL:
  https://stacks.cdc.gov/view/cdc/201428/cdc_201428_DS1.pdf
• File Type:
  [PDF - 322.47 KB ]