Reduced Basal Levels and Enhanced LPS Response of IL-6 mRNA in Aged Mice

Details

• Personal Author:
  Bondy SC ; Campbell A ; Sharman E ; Sharman K
• Description:
  Senescence is a complex and multifactorial process that may predispose organisms to altered responses to environmental stressors. The cytokine interleukin-6 (IL-6) is expressed by a variety of cells and is one of the earliest mediators of the acute inflammatory response. In this study, the level of IL-6 mRNA in younger (7 months) and old (23 months) mice was determined in the tissue of several organs with or without stimulation with lipopolysaccharide (LPS). Whereas younger animals had a basal expression of IL-6 mRNA in all organs, this was undetectable in the old animals. In contrast, when the mice were injected with LPS, in a majority of the organ tissues there was a robust stimulation of IL-6 mRNA in the old mice whereas the younger animals had a more variable response. These data indicate that the aging process may predispose animals to an exaggerated and potentially harmful inflammatory response. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Animals Immune System Occupational Health Safety
• Keywords:
  Age Factors Animal Studies Biological Effects Cytokines Environmental Stress Immune Reaction
• ISSN:
  1079-5006
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  56
• Issue:
  12
• NIOSHTIC Number:
  nn:20058220
• Citation:
  J Geront, Ser A Biol Sci Med Sci 2001 Dec; 56(12):B520-B523
• Contact Point Address:
  S.C. Bondy, Department of Community & Environmental Medicine, University of California, Irvine, Irvine, CA 92697-1825
• Email:
  scbondy@uci.edu
• Federal Fiscal Year:
  2002
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  True
• Start Date:
  19990701
• Source Full Name:
  The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c15e01e644b4990b2788fd9c4e007d971f7bc131965dbd71608b15298d190c8d62370e05d60477a886e0d5783fc56d66554713899cea28fc2c3f1a4bd2500046
• Download URL:
  https://stacks.cdc.gov/view/cdc/221353/cdc_221353_DS1.pdf
• File Type:
  [PDF - 115.61 KB ]