Lack of an Exposure Response and Interaction with HLA-DPβ1 and DRβ1 Polymorphisms in the Development of Beryllium Toxicity in a High Beryllium Exposure Cohort

Details

• Personal Author:
  Gardiner JC ; Monos D ; Pathak DR ; Reilly MJ ; Rice C ; Rosenman, Kenneth D. ; Rossman M ; Wang L ; Widyaningsih V
• Description:
  OBJECTIVE: To evaluate interaction of HLA-DPbeta1 and DRbeta1 polymorphisms with metrics of beryllium exposure, in the development of beryllium sensitization (BeS) and chronic beryllium disease (CBD). METHODS: A matched case-control study of 61 CBD, 41 BeS, and 259 controls from two beryllium-processing facilities. RESULTS: BES and CBD were significantly associated with presence of DPbetaE69. Dose response of exposure was not observed for the development of BES and CBD with/without adjustment for DPbetaE69 (P > 0.05). The DRbetaE71 polymorphism was more common in BeS than CBD after adjusting for exposure and maybe a protective factor (aOR 0.4, 95% CI 0.2 to 0.9) against the progression of BeS to CBD. CONCLUSION: No exposure-response association was found, which may reflect that the workers in this high exposure cohort were above a threshold level where an exposure-response could be observed. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Genetics Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Beryllium Beryllium Disease Cohort Studies Dose Response Genes Genetic-exposure Interaction Genotoxicity Human Leukocyte Antigen Polymorphisms Lung Disorders Respiratory System Disorders
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  64-73
• Volume:
  62
• Issue:
  1
• NIOSHTIC Number:
  nn:20058168
• Citation:
  J Occup Environ Med 2020 Jan; 62(1):64-73
• Contact Point Address:
  Ling Wang, PhD, Michigan State University, 909 Wilson Road, Room 120 West Fee, East Lansing, MI 48864
• Email:
  wangli35@msu.edu
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2020
• Performing Organization:
  Michigan State University
• Peer Reviewed:
  True
• Start Date:
  20030801
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20070731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8660c2570af58b57a1f66afa2979be080987137a61e0a212908f2af900b1b2cfc95bfdfb09fe3dc9a5229177718592d27e5b5eb65a2f2509ebd1d8be8574b8af
• Download URL:
  https://stacks.cdc.gov/view/cdc/221305/cdc_221305_DS1.pdf
• File Type:
  [PDF - 428.55 KB ]