MUC5B Promoter Variant and Survival in Rheumatoid Arthritis-Associated Interstitial Lung Disease

Details

• Personal Author:
  Ascherman DP ; Baker JF ; Cannon GW ; England BR ; Frideres H ; Kerr GS ; Klein J ; Kunkel GA ; Mikuls TR ; Monach PA ; Poole JA ; Reimold A ; Roul P ; Thiele GM ; Wheeler A ; Wysham KD ; Yang Y
  More +
• Description:
  Objective: The objective of this study was to investigate the association between the MUC5B rs35705950 promoter variant and survival in RA-associated interstitial lung disease (RA-ILD). Methods: We studied participants in the Veteran Affairs Rheumatoid Arthritis (VARA) registry with validated ILD diagnoses. Participants were followed until death or till the end of the study period. The MUC5B rs35705950 promoter variant was measured using an Infinium genotyping array, assuming autosomal dominant inheritance. Survival and cause of death were determined from VA death records and the National Death Index. Associations of the MUC5B promoter variant with survival were tested in Cox regression models, adjusting for potential confounders. Results: Among 263 participants with RA-ILD (mean age 69 years, 95% male, 73% White, 85% smoking history), the MUC5B promoter variant was present in 33.5%. The mortality rate was similar between those with 12.2/100 PY (95% CI: 9.4, 15.8) and without 11.1/100 PY (95% CI: 9.1, 13.5) the variant. MUC5B status was not significantly associated with survival overall aHR 0.97 (95% CI: 0.68, 1.37) or when stratified by ILD pattern clinical usual interstitial pneumonia (UIP) aHR 0.86 (95% CI: 0.55, 1.35); clinical non-UIP aHR 1.15 (95% CI: 0.63, 2.09). Further, MUC5B status was not significantly associated with respiratory-related aHR 0.83 (95% CI: 0.42, 1.66) or non-respiratory causes of death aHR 1.08 (95% CI: 0.72, 1.62). Conclusion: While associated with RA-ILD risk, the MUC5B promoter variant was not predictive of survival among RA-ILD patients in this multicentre cohort. Further studies are needed to identify other genetic and non-genetic prognostic factors in RA-ILD to inform disease management. Description provided by NIOSH
• Subjects:
  • Cohort Studies
  • Genetics
  • Lung Diseases
  • Occupational Health
  • Respiratory Tract Diseases
  • Safety
• Keywords:
  • Military personnel
  • Rheumatoid disorders
  • Lung disease
  • Genetic factors
  • Genetics
  • Survival rate
  • Cohort studies
  • Author Keywords: rheumatoid arthritis
  • interstitial lung disease
  • genetics
  More +
• ISSN:
  1462-0324
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Boston Region OSHA ; Dallas Region OSHA ; Denver Region OSHA ; District of Columbia ; Kansas City Region OSHA ; Massachusetts ; Nebraska ; Pennsylvania ; Philadelphia Region OSHA ; San Francisco Region OSHA ; Texas ; Utah ; Washington
  More +
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20070745
• Citation:
  Rheumatology 2024 Nov; :Epub ahead of print
• Email:
  Bryant.england@unmc.edu
• Federal Fiscal Year:
  2025
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center
• Peer Reviewed:
  True
• Start Date:
  20210901
• End Date:
  20250831
• Download URL:
  https://stacks.cdc.gov/view/cdc/208914/cdc_208914_DS1.pdf
• File Type:
  [PDF - 730.75 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d3d54b698a61eae5df9eb6e3e6ecd64adcb3ed60e5cac463952750e5136e9e9d3f50eb0d4a5ae7fd5568d2cd6504033bbbe1d4f52a02017fc80714bfbb204181