MUC5B Promoter Variant and Survival in Rheumatoid Arthritis-Associated Interstitial Lung Disease

Details

• Personal Author:
  Ascherman DP ; Baker JF ; Cannon GW ; England BR ; Frideres H ; Kerr GS ; Klein J ; Kunkel GA ; Mikuls TR ; Monach PA ; Poole JA ; Reimold A ; Roul P ; Thiele GM ; Wheeler A ; Wysham KD ; Yang Y
• Description:
  Objective: The objective of this study was to investigate the association between the MUC5B rs35705950 promoter variant and survival in RA-associated interstitial lung disease (RA-ILD). Methods: We studied participants in the Veteran Affairs Rheumatoid Arthritis (VARA) registry with validated ILD diagnoses. Participants were followed until death or till the end of the study period. The MUC5B rs35705950 promoter variant was measured using an Infinium genotyping array, assuming autosomal dominant inheritance. Survival and cause of death were determined from VA death records and the National Death Index. Associations of the MUC5B promoter variant with survival were tested in Cox regression models, adjusting for potential confounders. Results: Among 263 participants with RA-ILD (mean age 69 years, 95% male, 73% White, 85% smoking history), the MUC5B promoter variant was present in 33.5%. The mortality rate was similar between those with [12.2/100 PY (95% CI: 9.4, 15.8)] and without [11.1/100 PY (95% CI: 9.1, 13.5)] the variant. MUC5B status was not significantly associated with survival overall [aHR 0.97 (95% CI: 0.68, 1.37)] or when stratified by ILD pattern [clinical usual interstitial pneumonia (UIP) aHR 0.86 (95% CI: 0.55, 1.35); clinical non-UIP aHR 1.15 (95% CI: 0.63, 2.09)]. Further, MUC5B status was not significantly associated with respiratory-related [aHR 0.83 (95% CI: 0.42, 1.66)] or non-respiratory causes of death [aHR 1.08 (95% CI: 0.72, 1.62)]. Conclusion: While associated with RA-ILD risk, the MUC5B promoter variant was not predictive of survival among RA-ILD patients in this multicentre cohort. Further studies are needed to identify other genetic and non-genetic prognostic factors in RA-ILD to inform disease management. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Genetics Lung Diseases Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Rheumatoid Arthritis Cohort Studies Genetic Factors Interstitial Lung Disease Lung Disease Military Personnel Rheumatoid Disorders Survival Survival Rate
• ISSN:
  1462-0324
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Boston Region [OSHA] ; Dallas Region [OSHA] ; Denver Region [OSHA] ; District of Columbia ; Kansas City Region [OSHA] ; Massachusetts ; Nebraska ; Pennsylvania ; Philadelphia Region [OSHA] ; San Francisco Region [OSHA] ; Texas ; Utah ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20070745
• Citation:
  Rheumatology 2024 Nov; :[Epub ahead of print]
• Contact Point Address:
  Bryant England, Department of Internal Medicine, Division of Rheumatology & Immunology, VA Nebraska Western Iowa Health Care System & University of Nebraska Medical Center, 986270 Nebraska Medicine, Omaha, NE 68198-6270, USA
• Email:
  Bryant.england@unmc.edu
• Federal Fiscal Year:
  2025
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center
• Peer Reviewed:
  True
• Start Date:
  20210901
• Source Full Name:
  Rheumatology
• End Date:
  20250831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d3d54b698a61eae5df9eb6e3e6ecd64adcb3ed60e5cac463952750e5136e9e9d3f50eb0d4a5ae7fd5568d2cd6504033bbbe1d4f52a02017fc80714bfbb204181
• Download URL:
  https://stacks.cdc.gov/view/cdc/208914/cdc_208914_DS1.pdf
• File Type:
  [PDF - 730.75 KB ]