Protein Binding, Sister Chromatid Exchange and Expression of Oncogene Proteins in Patients Treated with Cisplatinum (cisDDP)-Based Chemotherapy

Details

• Personal Author:
  Brandt-Rauf P ; Fischman HK ; Hemminki K ; Niman HL ; O'Dowd K ; Perera F ; Smith S ; Stoopler M ; Tang MX ; Toporoff E ; Tsai WY
• Description:
  The aim of this pilot was to evaluate the feasibility of incorporating several complementary biologic markers into a molecular epidemiologic study of chemotherapy patients. Thirty-two cancer patients being treated withcis-DDP-based chemotherapy for the first time were enrolled in the study and donated a baseline sample and at least one post-treatment sample of blood. Sister Chromatid Exchange (SCEs) and plasma protein and hemoglobin binding bycisDDP were significantly increased in samples drawn at various timepoints following treatment. The pattern of nine different oncogene protein products (including those ofras, fes, andmyc) remained unchanged in sera of six patients followed over the course of their treatment. However, the levels ofras P21 product were significantly elevated above normal, control levels in all six cancer patients - both prior to and throughout the course of chemotherapy. These results suggest the usefulness of utilizing a battery of markers to evaluate biologic response to cisplatinum-based chemotherapy. [Description provided by NIOSH]
• Subjects:
  Biomarkers Epidemiology Neoplasms Occupational Health Safety
• Keywords:
  Author Keywords: Carcinogen-protein Binding Biological Effects Biological Monitoring Biologic Markers Chemotherapy Cisplatinum Oncogene Activation Oncogenic Agents Sister Chromatid Exchange
• ISSN:
  0340-5761
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  401-406
• Volume:
  64
• Issue:
  5
• NIOSHTIC Number:
  nn:20058147
• Citation:
  Arch Toxicol 1990 Jul; 64(5):401-406
• Contact Point Address:
  F. Perera, Columbia University School of Public Health, Division of Environmental Sciences, 60 Haven Ave, B-109, NY, NY 10032, USA
• CAS Registry Number:
  Cisplatin (CAS RN 15663-27-1)
• Federal Fiscal Year:
  1990
• Performing Organization:
  Columbia University New York, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19890715
• Source Full Name:
  Archives of Toxicology
• End Date:
  19930114
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:713f97a70e14560fdc583c85404b7319040efff217927ccb5a73fa6433ab753ad5cd193b205e29ebc3103a18a7133432b6490037198160f42f2a9fb805c8a390
• Download URL:
  https://stacks.cdc.gov/view/cdc/221288/cdc_221288_DS1.pdf
• File Type:
  [PDF - 730.78 KB ]