Using Molecular Epidemiology in Assessing Exposure for Risk Assessment

Details

• Personal Author:
  Schulte, Paul A. ; Waters M
• Description:
  Quantitative estimation of health risks depends on exposure characterization, the nature of the dose response relationships, and the toxicity of the agents involved. The greatest uncertainties in risk assessment almost always arise from sparse or inadequate exposure data, inadequate understanding of exposure mechanisms, and insufficient understanding of the exposure-dose-response pathway. Additional sources of uncertainty arise when mixed or multiple exposures are implicated in the disease pathway, and as a result of variability in both exposures and responses within and between individuals. Here we consider the role of exposure assessment in the risk assessment process, the use of biological markers or molecular epidemiology to contribute to improvements in exposure assessment for risk assessment, and uncertainties associated with the use of biological markers. [Description provided by NIOSH]
• Subjects:
  Biomarkers Environmental Monitoring Epidemiology Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Analytical-methods Analytical-processes Biological-effects Biological-monitoring Dose-response Exposure-assessment Quantitative-analysis Risk-analysis Risk-factors Statistical-analysis
• ISBN:
  9781573312363
• ISSN:
  0077-8923
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New York ; Ohio ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  101-111
• Volume:
  895
• Issue:
  1
• NIOSHTIC Number:
  nn:20027527
• Citation:
  Ann NY Acad Sci 1999 Dec; 895(1):101-111
• Contact Point Address:
  National Institute for Occupational Safety and Health, Education and Information Division, Risk Evaluation Branch, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA
• Email:
  pas4@cdc.gov
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Annals of the New York Academy of Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cc7a50dcb154cc9b112a395ad9af17f8d1934ba56c6d1eada817c8bdc2ab4aabaea327eb2fc49503a0a7580962458c7c04f62eced031bd19752d0bcb30864899
• Download URL:
  https://stacks.cdc.gov/view/cdc/197595/cdc_197595_DS1.pdf
• File Type:
  [PDF - 400.22 KB ]