Permeation of Captan Formulation Through Nitrile Protective Glove Material

Details

• Personal Author:
  Phalen R ; Que Hee SS
• Description:
  Wettable powders of the fungicide captan (CASRN #133-06-2) are applied in agriculture by spraying over fields, applying onto the soil, or by dipping roots to be planted into a concentrated solution. Potential for dermal contact exists with such applications, the manufacture of captan, and its formulating. However, there are no permeation data available. The aim of this study was to assess the permeation of a wettable-powder formulation (48.9% captan and 1.1 % related derivatives) as it would be sprayed in agriculture. A popular disposable nitrile glove material, Safeskin Blue Nitrile of 0.116 +/- 0.004 mm thickness, was evaluated. Testing involved using the I-PTC 600 permeation cell in accordance with the American Society for Testing Materials (ASTM) F739-96 method, "Standard Test Method for Resistance of Protective Clothing Materials to Permeation by Liquids or Gases Under Conditions of Continuous Contact". A worst-case aqueous concentration of 217 mg/mL of the 50% wettable powder was tested to maximize permeation. The collection medium was hexane. Samples were collected at 2, 4, and 8-hour intervals. Analysis was conducted using nonpolar capillary column gas chromatography (GC) with electron capture detection (ECD) and mass spectrometry (MS). The GCIECD least quantifiable limit was about 6 ng whereas that for GCIMS was approximately 30 ng at m/z 79. The collection medium had to be concentrated before an aliquot was injected. The calculated permeation rate by GCIECD was about 600 pg/cm2/min after 8 hours, a very low rate. [Description provided by NIOSH]
• Subjects:
  Fungi Fungicide, Industrial Insecticides Nitriles Occupational Health Personal Protective Equipment Protective Clothing Safety Skin
• Keywords:
  Captan Fungicides Gloves Hand Protection Pesticides And Agricultural Chemicals Skin Exposure
• Publisher:
  American Industrial Hygiene Association
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  34
• NIOSHTIC Number:
  nn:20058111
• Citation:
  American Industrial Hygiene Conference and Exposition, June 1-6, 2002, San Diego, California. Fairfax, VA: American Industrial Hygiene Association, 2002 Jun; :34
• CAS Registry Number:
  Captan (CAS RN 133-06-2)
• Federal Fiscal Year:
  2002
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  False
• Start Date:
  20000630
• Source Full Name:
  American Industrial Hygiene Conference and Exposition, June 1-6, 2002, San Diego, California
• End Date:
  20040531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6bc51787287016c5bcab70c2d1e6b38e2bf15b36641e518e54b71a2d7e4c1465469b1c5f7c767f86c0e6b985f4daab0bea8aa180951ddb666e14f604c30c218f
• Download URL:
  https://stacks.cdc.gov/view/cdc/221257/cdc_221257_DS1.pdf
• File Type:
  [PDF - 318.04 KB ]