An Aluminum-Induced Increase in GFAP Is Attenuated by Some Chelators

Details

• Personal Author:
  O'Callaghan JP ; Yokel RA
• Description:
  Enhanced expression of glial fibrillary acidic protein (GFAP) has been shown to be associated with gliosis, a generic response of the CNS to neural injury. The effects of aluminum (Al) on regional GFAP concentrations were evaluated to determine potential sites of Al-induced neural injury. Rabbits received 20 Al (100 mumol/kg) or sodium lactate injections over 1 month. Frontal cortical GFAP increased (approximately twofold above control) in Al-loaded rabbits; whereas hippocampal and cerebellar GFAP concentrations were not affected. Frontal cortical synaptophysin, neurofilament 68, and myelin basic protein concentrations were then examined in an attempt to determine cell-specific targets of Al neurotoxicity. These proteins were not affected by Al. The ability of chelators to influence brain Al concentrations and the Al effect on GFAP were assessed. Desferrioxamine (DFO) and six 3-hydroxypyridin-4-ones (CPs) were given 12 times, over 1 month, to Al-loaded rabbits. CP24 significantly reduced brain Al. CP93, CP52, and CP24 significantly reduced frontal cortical GFAP. The data suggest an Al-induced gliosis consequent to subtle damage in the frontal cortex and a protective role of some chelators against this CNS injury. [Description provided by NIOSH]
• Subjects:
  Aluminum Compounds Animals Laboratories Nervous System Occupational Health Safety
• Keywords:
  Aluminum-compounds Animal-studies Central-nervous-system Laboratory-animals Neurotoxic-effects Neurotoxicity
• ISSN:
  0892-0362
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Kentucky ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  55-60
• Volume:
  20
• Issue:
  1
• NIOSHTIC Number:
  nn:20025503
• Citation:
  Neurotoxicol Teratol 1998 Jan-Feb; 20(1):55-60
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5)
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  True
• Source Full Name:
  Neurotoxicology and Teratology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e09343fdb5883feeb0ba8ba8b32a5bde5aa0eeda1bdbef04f0c83f55f80c438f3e0823de3f2c0c6b0e1ad35033811d91ab2cac2b3e90b0850e928229e2094abb
• Download URL:
  https://stacks.cdc.gov/view/cdc/196838/cdc_196838_DS1.pdf
• File Type:
  [PDF - 144.39 KB ]