Details:

Alternative Title:
Pediatr Infect Dis J
Publisher's site:
http://dx.doi.org/10.1097/INF.0000000000000085
Personal Author:
Loo, Jennifer D. ; Conklin, Laura ; Deloria Knoll, Maria ; Fleming-Dutra, Katherine E. ; Park, Daniel E. ; ... More +
Loo, Jennifer D. ; Conklin, Laura ; Deloria Knoll, Maria ; Fleming-Dutra, Katherine E. ; Park, Daniel E. ; Kirk, Jennifer ; Johnson, T. Scott ; Goldblatt, David ; O’Brien, Katherine L. ; Whitney, Cynthia G. Less -
Description:
Background:

Streptococcus pneumoniae causes a considerable amount of morbidity and mortality in children <5. However, pneumococcal conjugate vaccines (PCVs) can prevent much of this burden. Until recently, PCVs were mostly available only in developed countries using a variety of dosing schedules. As more lower income countries make decisions to introduce PCV into their national immunization programs, an optimal schedule with which to administer PCV has become a key policy question.

Methods:

We performed a systematic review of English literature published from 1994 to 2010 on the effects of PCV dosing schedules on immunogenicity, nasopharyngeal carriage, invasive pneumococcal disease and pneumonia. Data were independently double abstracted and cleaned for analysis. Descriptive analyses were performed.

Results:

We identified 12,980 citations from the literature search (12,976) and secondary means (44). Double review of titles and abstracts yielded 769 articles that underwent full data abstraction. Of these, 350 were further analyzed and are presented in separate reports in this supplement.

Conclusions:

This article presents the methods utilized in our systematic review. Because of the heterogenity of the study methods of the reports identified by this review, we did not conduct formal meta-analyses. However, these methods allow us to present a full landscape of the literature on PCV dosing schedules.


Subject:
[+]
Child, Preschool
Data Mining
Humans
Immunization Schedule
Infant
Methods
Methods Appendix
Pneumococcal Conjugate Vaccine
Pneumococcal Infections
Pneumococcal Vaccines
Systematic Review
Vaccines, Conjugate
Immunization Schedule

Source:
Pediatr Infect Dis J. 2014; 33(Suppl 2 Optimum Dosing of Pneumococcal Conjugate Vaccine For Infants 0 A Landscape Analysis of Evidence Supportin g Different Schedules):S182-S187.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ab81e95de7c12036840a57242dd12cbbcc1ee19c59ec36837a61a265e029b166
File Type:

Supporting Files

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  	inf-33-S182.nxml	txt
  	license.txt	txt

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