Combined Analysis of Lung Cancer Among Uranium Miners

Details

• Personal Author:
  Richardson DB
• Description:
  The objective of this project was to conduct a pooled analysis of major cohorts of uranium miners selected based on cohort size, availability of demographic and employment information, and completeness of radon exposure data. It has been over two decades since the US National Cancer Institute reported on a highly-influential pooled analysis of underground miners. Since that time, epidemiological cohorts of underground miners have been substantially updated and expanded, and important developments have occurred in the methods for statistical analyses of longitudinal data. This combined study of uranium miners was undertaken to strengthen the basis for protection of contemporary workers from the carcinogenic effects of radon progeny, and to improve understanding of the risks faced by workers who were exposed in the past. The pooling has permitted us to address questions regarding variation in mortality risks with exposure, risks associated with lower level exposures more typical of contemporary settings, as well as variation in risks by type of cancer. Because a causal interpretation of epidemiological findings is strengthened by evidence of reproducibility and consistency, we assessed the consistency of results derived from analysis of US underground miner cohorts with associations observed in other international cohorts. The international combined analysis, called PUMA, was undertaken and these data yield the most statistically powerful analysis of radon risks among miners reported to-date. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Epidemiology Lung Lung Diseases Mining Mortality Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety Uranium

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• Keywords:
  Cohort Studies Lung Cancer Mortality Data Radon Statistical Analysis Underground Miners Uranium Miners
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-14
• NIOSHTIC Number:
  nn:20057012
• NTIS Accession Number:
  PB2019-101424
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R03-OH-010946, 2019 Feb; :1-14
• Contact Point Address:
  David Richardson, Department of Epidemiology, McGavran-Greenberg Hall, School of Public Health, CB#7435 University of North Carolina, Chapel Hill, NC 27599-7435
• Email:
  david.richardson@unc.edu
• CAS Registry Number:
  Radon (CAS RN 10043-92-2) ; Uranium (CAS RN 7440-61-1)
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Mining ; Oil and Gas Extraction
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  False
• Start Date:
  20150901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:da1e39da13b566c5cf234ca6cd45274feb7bd88d37f55be2892a1c96b96768eeeff9de4a9f95621ce3d5375d5ab69231776fd00c0bcf5bc4c2c94d9376c0edb1
• Download URL:
  https://stacks.cdc.gov/view/cdc/218922/cdc_218922_DS1.pdf
• File Type:
  [PDF - 77.63 KB ]