Longitudinal Study of Respiratory Function in Aluminum Smelter Workers

Details

• Personal Author:
  Gulati M
• Description:
  Specific Aims: The specific aims of this K01 remain unchanged and are briefly reviewed below: Specific Aim 1a and 1b: Delineate two cohorts, an overall (1a) and an inception cohort (1b), of exposed smelter workers for whom basic demographic data as well as data concerning date of hire, job tasks and exposures, medical claims information and spirometric function tests are available. Specific Aim 2a & 2b: Determine the change over time, or slope, of the principle parameters of spirometric function including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and maximal midexpiratory flow rates (MMEF) among workers in the overall cohort (2a) and inception subcohort (2b) Specific Aim 3a & 3b: Using insurance claims data, measure the incidence and prevalence of obstructive lung disease (OLD) and of subgroups of asthma and COPD among the overall cohort (3a) and inception subcohort (3b). Specific Aim 4a & 4b: Determine the concordance between change over time, or slope, in the principle parameters of spirometric function and the diagnosis of OLD and of subgroups of asthma and COPD in the overall cohort and inception subcohort. Specific Aim 5a & 5b: Measure the association between exposure to total and respirable particulate matter and change over time in spirometric function (5a) and the diagnosis of OLD (5b) in the overall cohort and inception subcohort. Specific Aim 6a & 6b: Measure the association between each of the principle exposures commonly found in aluminum smelters, including fluorides (gaseous, particulate and total), sulfur dioxide, oil mist and coal tar pitch volatiles, and change over time in spirometric function (6a) and the diagnosis of OLD (6b) in the overall cohort and inception subcohort. Specific Aim 7a & 7b: Explore the role of smoking as an effect modifier of longitudinal changes in spirometric function (7a) and the diagnosis of OLD (7b) in the overall cohort and inception subcohort. Specific Aim 8a & 8b: Develop a multivariate model including demographic predictors, smoking status and the exposures to predict change over time in spirometric function (8a) and the incidence of OLD diagnosis (8b). [Description provided by NIOSH]
• Subjects:
  Aluminum Compounds Asthma, Occupational Cohort Studies Metals Metal Workers Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Aluminum Cohort Studies Longitudinal Study Occupational Asthma Particulates Respiratory Function Smelters Smelting
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-2
• NIOSHTIC Number:
  nn:20056909
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, K01-OH-008644, 2012 Mar; :1-2
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Yale University, New Haven, Connecticut
• Peer Reviewed:
  False
• Start Date:
  20060901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20100831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5f3c2ad908d426055f58b0bf569034e81160e0439538ccc975f26f7d0c2b67118cdeae681a405b64ac45030c95bed2f9460db8837b98ed6226151bbcb8f31713
• Download URL:
  https://stacks.cdc.gov/view/cdc/218917/cdc_218917_DS1.pdf
• File Type:
  [PDF - 45.47 KB ]