Combined Analysis of Mortality Among Nuclear Workers

Details

• Personal Author:
  Richardson DB
• Description:
  The objective of this project was to conduct a pooled analysis of US worker data for employees of 5 major facilities selected based on cohort size, availability of demographic and employment history information, and completeness of radiation monitoring data: Oak Ridge National Laboratory, Savannah River Site, Hanford site, Idaho National Laboratory, and Portsmouth Naval Shipyard. An update of vital status follow-up of each cohort had been conducted recently, making the proposed analysis feasible. The combined study of US workers was undertaken and has permitted us to address questions regarding variation in radiation risks with time-since-exposure and age-at-exposure, as well as variation in radiation risks by type of cancer. We proposed state-of-the-art methods to minimize bias due to confounding, sensitivity analyses to assess the impact of exposure misclassification, and innovative regression models to assess effect measure modification and between-cohort heterogeneity in radiation risks. Moreover, a causal interpretation of epidemiological study findings is strengthened by evidence of reproducibility and consistency. Therefore, we proposed to empirically assess the consistency of results derived from US nuclear worker data with results derived from UK and French nuclear worker cohorts, two nations that also developed large nuclear programs. An international combined study, called INWORKS, was undertaken. The international combined data yields the most statistically powerful analysis of radiation risk among nuclear workers reported to-date. [Description provided by NIOSH]
• Subjects:
  Demography Epidemiology Neoplasms Nuclear Power Plants Occupational Health Radiation Risk Assessment Risk Factors Safety Workplace
• Keywords:
  Cancer Demographic-characteristics Exposure-levels Models Nuclear-hazards Nuclear-power-plants Nuclear-properties Radiation-levels Radiation-measurement Risk-factors Work-environment Workers

  More +
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-9
• NIOSHTIC Number:
  nn:20047131
• NTIS Accession Number:
  PB2016-101846
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R03-OH-010056, 2015 Feb; :1-9
• Contact Point Address:
  David Richardson, Department of Epidemiology, McGavran-Greenberg Hall, School of Public Health, CB#7435 University of North Carolina, Chapel Hill, NC 27599-7435
• Email:
  david.richardson@unc.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  False
• Start Date:
  20110901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20140630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:51a99f2c805ef7f69fa711be7a25ae29ac503b6a18331abf25b6691277ec322da01cd80f863bdc360dcbf166dd96b051faea0906f457150aacde1d4c75962564
• Download URL:
  https://stacks.cdc.gov/view/cdc/218608/cdc_218608_DS1.pdf
• File Type:
  [PDF - 37.64 KB ]