Safe Alternative Solvents for Antibiotics Extraction

Details

• Personal Author:
  Clark JF ; Evenson CE ; Clark JF ; Evenson CE
• Description:
  This research resulted in identification of non-volatile, non-flammable room temperature ionic liquids (RTIL's) to replace the toxic, flammable, volatile organic compound (VOC) solvents now used for extraction of antibiotics from fermentation broths. The solvents used for penicillin extraction include methyl isobutyl ketone, amyl acetate, butyl acetate, and chloroform. These solvents are toxic, irritants, volatile, and/or extremely flammable. RTIL's have attracted significant attention for green chemistry applications. They are ionic compounds that have very large liquidus ranges. Some are air and water stable and immiscible with water. They solubilize aromatics and carbonyl-containing compounds particularly well, and were found to be effective for penicillin-G extraction. RTIL's have previously been studied for liquid-liquid extraction and other separations.. Being non-volatile, they are recyclable, and their large liquidus ranges allow efficient separations using temperature control. They are non-flammable, and are "tunable" solvents, as the cations can be substituted and/or paired with different anions to manipulate the properties of the liquids and tailor them for specific applications. The use of RTIL's instead of the toxic, flammable, VOC solvents now used would improve the health and safety of pharmaceutical workers, and reduce costs, since they are straightforward to synthesize. New processes or equipment would not be required. [Description provided by NIOSH]
• Subjects:
  Anti-Bacterial Agents Biopharmaceutics Chemistry Occupational Health Pharmacies Safety Solvents
• Keywords:
  Antibiotics Chemical-extraction Chemical-structure Chemical-synthesis Control-technology Pharmaceutical-industry Pharmaceuticals
• Series:
  Grant Final Reports   ; Grant Final Reports  
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report ; Final Grant Report
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs ; OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  1-16
• NIOSHTIC Number:
  nn:20023748
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R43-OH-007466, 2002 Jul; :1-16
• Contact Point Address:
  Eltron Research, Inc, 4600 Nautilus Court South, Boulder, Colorado 80301-3241
• CAS Registry Number:
  5-Methyl-2-hexanone (CAS RN 110-12-3) ; Amyl acetate (CAS RN 628-63-7) ; Butyl acetate (CAS RN 123-86-4) ; Chloroform (CAS RN 67-66-3) ; Potassium (CAS RN 7440-09-7) ; 5-Methyl-2-hexanone (CAS RN 110-12-3) ; Amyl acetate (CAS RN 628-63-7) ; Butyl acetate (CAS RN 123-86-4) ; Chloroform (CAS RN 67-66-3) ; Potassium (CAS RN 7440-09-7)
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Research Tools and Approaches: Control Technology and Personal Protective Equipment ; Research Tools and Approaches: Control Technology and Personal Protective Equipment
• Performing Organization:
  Eltron Research, Inc., Boulder, Colorado
• Peer Reviewed:
  False
• Start Date:
  20010930
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20020930
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7afe2ab83350e4d2370574817e65bf967729d9487cba330fc102b6b8d77c151e47b65ce3e8597be3b367bdfd1786c190f5cad47fbb416c53a300612fd3ffbab6
• Download URL:
  https://stacks.cdc.gov/view/cdc/218106/cdc_218106_DS1.pdf
• File Type:
  [PDF - 2.46 MB ]