Activation of H-Ras Oncogene by Drinking Water Disinfectant By-Products

Details

• Personal Author:
  Velazquez SF
• Description:
  The frequency and spectrum of H-ras oncogene activation by the water disinfection by products 2-chloroacetaldehyde (107200) (CAA), chloral-hydrate (302170) (CH), and dichloroacetic-acid (79436) (DCA) was investigated in the livers of male B6C3F1-mice. Mice had been administered high doses of these chemicals over a 2 year period. No mutations were noted in the H-ras oncogene in any normal liver tissue samples taken from mice with hepatocellular carcinomas. Codon 12/13 mutations were not present in any samples of either tumor tissues or normal liver. A relatively low frequency of H-ras activation was noted for liver tumors in mice dosed with CAA. For mice administered CH, a very low frequency of H-ras activation was found for liver tumors. A higher frequency of H-ras mutation was found for liver tumors in mice administered DCA. The authors conclude that the induction of the hepatocellular carcinomas by CAA does not involve the activation of the H-ras oncogene. The authors suggest that while DCA is most likely not directly causing these H- ras mutations, the proliferative action of DCA on the liver may be preferentially promoting cells containing ras mutations. [Description provided by NIOSH]
• Subjects:
  Carcinogens Hydrocarbons Laboratories Liver Mutagens Neoplasms Occupational Exposure Occupational Health Safety
• Keywords:
  Cancer Chlorinated-hydrocarbons Chronic-exposure Laboratory-animals Liver-cancer Liver-cells Mutagenesis NIOSH-Grant Tumorigenesis
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-43
• NIOSHTIC Number:
  nn:00225279
• NTIS Accession Number:
  PB95-200515
• Citation:
  Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio 1994 Apr; :1-43
• Contact Point Address:
  Environmental Health Univ of Cincinnati Coll of Med 3223 Eden Ave Cincinnati, OH 45267-0056
• CAS Registry Number:
  Chloral hydrate (CAS RN 302-17-0) ; Chloroacetaldehyde (CAS RN 107-20-0) ; Dichloroacetic acid (CAS RN 79-43-6)
• Federal Fiscal Year:
  1994
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  False
• Start Date:
  19890801
• Source Full Name:
  Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio
• End Date:
  19920731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:db7373060c228b992e2a9dab5ef838a73fcb706d39bfe62eeae27eab4271455c93cc0014e930c5bfd195617f80f8ccdab4a8381754f7baf4c44b7689652327ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/217843/cdc_217843_DS1.pdf
• File Type:
  [PDF - 1.46 MB ]