Oxygen Free Radicals in Pulmonary Fibrosis

Details

• Personal Author:
  Mossman BT ; Shatos MA ; Mossman BT ; Shatos MA
• Description:
  Studies conducted by the authors in the areas of lung cells, asbestos (1332214) and oxygen free radicals were summarized. The research resulted in considerable experience in lung cell culture development, the processing of an antiserum to the antioxidant enzymes superoxide-dismutase (SOD) and glutathione-peroxidase, and the completion of several studies which indicate that asbestos induced injury to lung cells in-vitro and in-vivo may be mediated by oxygen free radicals. Studies related to the development of the antiserum to SOD demonstrated the involvement of active oxygen species as mediators of injury by long asbestos fibers to the cells of the respiratory tract. Other studies demonstrated the unsuccessful phagocytosis of long fibers of asbestos coupled with the generation of oxygen free radicals which might explain the increased pathogenic potential of long fibers in asbestos associated diseases of the respiratory tract. Studies were also reviewed which focused on the possible role of oxygen free radicals on asbestos associated injury in normal lung fibroblasts, a target cell in pulmonary fibrosis. A short term inhalation model of asbestosis was developed in rodents to examine possible preventive approaches to lung disease. Occupational exposure to asbestos in man was associated with the development of pulmonary interstitial fibrosis. Several in-vitro studies suggested the involvement of active oxygen metabolites in cell damage caused by asbestosis. Studies were conducted which resulted in the confirmation of the importance of active oxygen species in asbestos related lung injury and suggested the possible future use of a novel therapeutic approach to clinical asbestosis. [Description provided by NIOSH]
• Subjects:
  Asbestos Enzymes Epidemiology Free Radicals Inorganic Chemicals Laboratories Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Asbestos-fibers Enzyme-activity Free-radicals Laboratory-animals Lung-cells NIOSH-Grant Pulmonary-system-disorders
• Series:
  Grant Final Reports   ; Grant Final Reports  
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report ; Final Grant Report
• Place as Subject:
  OSHA Region 1 ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs ; OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  1-7
• NIOSHTIC Number:
  nn:00192325
• NTIS Accession Number:
  PB90-154709
• Citation:
  Department of Pathology, University of Vermont, Burlington, Vermont 1989 Apr; :1-7
• Contact Point Address:
  Pathology University of Vermont Burlington, VT 05405
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  1989
• NORA Priority Area:
  Pulmonary System Disorders ; Pulmonary System Disorders
• Performing Organization:
  University of Vermont & St Agric College, Burlington, Vermont
• Peer Reviewed:
  False
• Start Date:
  19840928
• Source Full Name:
  Department of Pathology, University of Vermont, Burlington, Vermont
• End Date:
  19870831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e7fc68d8ea3f6159a6e2ee2d36613f15169ad25a1e6826d7adba4acddb1bb8d6ea74bbe6691e4aaa43bd6438c6e4d8bcbc91cf019ae40286b9f54a90c199e22c
• Download URL:
  https://stacks.cdc.gov/view/cdc/217774/cdc_217774_DS1.pdf
• File Type:
  [PDF - 413.21 KB ]