Dose-Effect Relationship of Asbestos Dust

Details

• Personal Author:
  Gross P
• Description:
  The pulmonary concentration of asbestos (1332214) dust was determined in rats which had inhaled asbestos dust or had been injected with this dust. Particular attention was given to the pulmonary concentration of asbestos dust in rats with cancer. This was compared to the amount of asbestos dust concentrated in the lungs of rats without cancer. A comparison was also made of the dust concentration in the lungs of rats where lung clearance was impaired and in rats with presumably normal clearance. The silica (14808607) content of the lungs of rats that had inhaled high concentrations of asbestos over a 16 month period was extremely low. The differences in the silica content between groups that had lung cancer and those that had no lung cancer was small. No group showed a decisive difference in pulmonary silica content. The lungs used in this study had been stored in formaldehyde solution for 5 to 6 years prior to analysis. Results indicated that lung tissue containing deposits of finely divided chrysotile dust may lose this dust by dissolution if kept submerged in aqueous formaldehyde solution for a prolonged period. The author recommends that asbestos determinations should be made on fresh lung tissue or on lung tissue that has been fume fixed after removal from the body and dried. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Asbestos Dust Inorganic Chemicals Laboratories Lung Lung Diseases Neoplasms Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety

  More +
• Keywords:
  Airborne-fibers Asbestos-fibers Dust-inhalation Fibrous-bodies Laboratory-animals Lung-cancer Mineral-dusts NIOSH-Grant Pulmonary-system-disorders
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-15
• NIOSHTIC Number:
  nn:00190687
• NTIS Accession Number:
  PB90-129859
• Citation:
  Industrial Health Foundation, Inc., Pittsburgh, Pennsylvania 1972 Oct; :1-15
• Contact Point Address:
  Industrial Health Foundation, Industrial Health Fdn, Inc 5231 Centre Avenue Pittsburgh, PA 15232
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  Industrial Health Foundation, Pittsburgh, Pennsylvania
• Peer Reviewed:
  False
• Start Date:
  19710501
• Source Full Name:
  Industrial Health Foundation, Inc., Pittsburgh, Pennsylvania
• End Date:
  19721031
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7b53cc7729b29e8fcf6d46f6ab76dfc3b530f6e0d1d8f98b66ecba39ec3b9d3416f3432c4beb2e4ae8a42b306501b33ac20168c53496bde1c2ac42fe34bf7385
• Download URL:
  https://stacks.cdc.gov/view/cdc/217770/cdc_217770_DS1.pdf
• File Type:
  [PDF - 433.50 KB ]