Neurotoxic Esterase and Neurotoxicity

Details

• Personal Author:
  Spencer PS
• Description:
  The relationship between the neuropathy target esterase (NTE) to organophosphorus (OP) compound interaction and the fate of retrograde transport of iodine-125 labeled tetanus-toxin was studied in hen sciatic nerve following a single subcutaneous injection of either a neurotoxic OP compound, a nonneurotoxic OP compound, or paraoxon (311455). In order to induce central peripheral distal axonopathy in these hens, a greater than 80 percent phosphorylation and subsequent intramolecular rearrangement of NTE in the nerve fiber were required. A progressive decrement of retrograde axonal transport in sensory and motor fibers that culminated, days later, in axon degeneration, was caused by suprathreshold biochemical reaction a few hours after dosing. Seven days after neurotoxic OP dosing the maximum transport deficit was reached; this was prior to the onset of nerve fiber degeneration and clinical signs of neuropathy. No effect on axon transport, nerve fiber integrity or clinical status was caused by nonneurotoxic OP. Paraoxon did not inhibit NTE and did not cause either deficit in retrograde transport or neuropathy. The author conclude that alterations in retrograde axonal transport may be important in the pathogenesis of nerve fiber degeneration in this and related toxic neuropathies. [Description provided by NIOSH]
• Subjects:
  Enzymes Nervous System Nervous System Diseases Occupational Health Organophosphates Safety
• Keywords:
  Enzyme-activity Nervous-system-disorders Neurotoxic-effects NIOSH-Grant Organo-phosphorus-compounds
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-2
• NIOSHTIC Number:
  nn:00182749
• NTIS Accession Number:
  PB89-129605
• Citation:
  Department of Neuroscience, Yeshiva University, Bronx, New York, 1986 Aug; :1-2
• Contact Point Address:
  Neuroscience Albert Einstein College of Med 1300 Morris Park Ave Bronx, N Y 10461
• CAS Registry Number:
  Paraoxon (CAS RN 311-45-5)
• Federal Fiscal Year:
  1986
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  False
• Start Date:
  19830901
• Source Full Name:
  Department of Neuroscience, Yeshiva University, Bronx, New York
• End Date:
  19860831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bc80e11a703863ec42d01ef5af055bbe3fb50606fcbcd0e87209df08b47651303165270ec76476039578b6ecb1c378475c056ab2adf7bc61b48701dc29394e80
• Download URL:
  https://stacks.cdc.gov/view/cdc/217747/cdc_217747_DS1.pdf
• File Type:
  [PDF - 182.02 KB ]