Influence of Welding Fume Metal Composition on Lung Toxicity and Tumor Formation in Experimental Animal Models

Details

• Personal Author:
  Antonini JM ; Falcone LM ; Zeidler-Erdely PC
• Description:
  Millions of workers in the United States and worldwide are exposed to complex, metal-rich welding fumes. Although welding is a crucial industrial process, the generated fumes are known to cause acute and chronic health effects when inhaled. The International Agency for Research on Cancer (IARC) classified welding fumes as carcinogenic to humans (Group 1) in 2017, based on sufficient epidemiological evidence and limited evidence in animals, an upgrade from the former Group 2B (possibly carcinogenic to humans) classification. There is evidence that both iron-abundant mild steel (MS) as well as chromium- and nickel-containing stainless steel (SS) welding fumes contribute to an increased risk of lung cancer. Recent animal studies show that welding fumes may act as lung tumor promoters, regardless of the presence or absence of potentially carcinogenic metals, such as chromium and nickel. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Animals Carcinogens Chemistry Chromium Epidemiology Ferrous Compounds Hazardous Substances Laboratories Lung Lung Diseases Metals Neoplasms Nickel Occupational Health Respiratory System Respiratory Tract Diseases Safety Welding

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• Keywords:
  Analytical Models Animal Studies Author Keywords: A/J Mice Carcinogenicity Chemical Composition Humans Iron Laboratory Animals Lung Cancer Metal Fumes Models Pulmonary System Disorders Respiratory System Disorders Stainless Steel Toxic Effects Toxic Fumes Tumors Welding Fumes

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• ISSN:
  1545-9624
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  372-377
• Volume:
  16
• Issue:
  6
• NIOSHTIC Number:
  nn:20055285
• Citation:
  J Occup Environ Hyg 2019 Jun; 16(6):372-377
• Contact Point Address:
  Patti C. Zeidler-Erdely, National Institutes for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road (M/S L2015), Morgantown, 26505 WV
• Email:
  paz9@cdc.gov
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3) ; Iron (CAS RN 7439-89-6) ; Nickel (CAS RN 7440-02-0) ; Stainless Steel (CAS RN 12597-68-1)
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Journal of Occupational and Environmental Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0530c0ce8b5f8980afbfd2c1fe3268dbd8cd72c59acda719928e251c0546bdd41da390984e41e7f35005ef191d058cc410343e5ec735d7d237d21261375885fc
• Download URL:
  https://stacks.cdc.gov/view/cdc/217626/cdc_217626_DS1.pdf
• File Type:
  [PDF - 780.03 KB ]