Influence of Viral Infection on the Relationships Between Airway Cytokines and Lung Function in Asthmatic Children

Details

• Personal Author:
  Batterman SA ; Brennan SR ; Carpenter AR ; Comstock AT ; Eder BN ; Goldsmith AM ; Hershenson MB ; Lewis TC ; Mentz GB ; Metitiri EE ; Mukherjee B ; Owens KB ; Ren X ; Ricci JM ; Robins TG ; the Community Action Against Asthma Steering Committee ; Washington GL ; Wicklund KE
• Description:
  Background: Few longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships. Methods: Children underwent home collections of nasal lavage during scheduled surveillance periods and self-reported respiratory illnesses. We studied 53 children for one year, analyzing 392 surveillance samples and 203 samples from 85 respiratory illnesses. Generalized estimated equations were used to evaluate associations between nasal lavage biomarkers (7 mRNAs, 10 proteins), lung function and viral infection. Results: As anticipated, viral infection was associated with increased cytokines and reduced FVC and FEV1. However, we found frequent and strong interactions between biomarkers and virus on lung function. For example, in the absence of viral infection, CXCL10 mRNA, MDA5 mRNA, CXCL10, IL-4, IL-13, CCL4, CCL5, CCL20 and CCL24 were negatively associated with FVC. In contrast, during infection, the opposite relationship was frequently found, with IL-4, IL-13, CCL5, CCL20 and CCL24 levels associated with less severe reductions in both FVC and FEV1. Conclusions: In asthmatic children, airflow obstruction is driven by specific pro-inflammatory cytokines. In the absence of viral infection, higher cytokine levels are associated with decreasing lung function. However, with infection, there is a reversal in this relationship, with cytokine abundance associated with reduced lung function decline. While nasal samples may not reflect lower airway responses, these data suggest that some aspects of the inflammatory response may be protective against viral infection. This study may have ramifications for the treatment of viral-induced asthma exacerbations. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Biomarkers Occupational Health Respiratory System Safety Viral Diseases
• Keywords:
  Author Keywords: Asthma Chemokine Children Cytokine FEV1 FVC Longitudinal Study Nasal Disorders Respiratory Function Rhinovirus Urban Viral Viral Infections

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• ISSN:
  1465-9921
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• NIOSHTIC Number:
  nn:20055193
• Citation:
  Respir Res 2018 Nov; 19:228
• Contact Point Address:
  Marc B. Hershenson, Departments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI 48109-5688, USA
• Email:
  mhershen@umich.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Respiratory Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:828e96aea190397902c01de2b6ec6a3e1fa78925da43e1234758c38c5aaaf98256b328209e266b4d0d9bb16853daddddf26eeb918536561b3bf5956437e9f7be
• Download URL:
  https://stacks.cdc.gov/view/cdc/217550/cdc_217550_DS1.pdf
• File Type:
  [PDF - 2.12 MB ]