Impact of Community Respiratory Viral Infections in Urban Children with Asthma

Details

• Personal Author:
  Batterman SA ; Brennan SR ; Comstock AT ; Eder BN ; Goldsmith AM ; Hershenson MB ; Lewis TC ; Mentz GB ; Metitiri EE ; Mukherjee B ; Owens KB ; Ren X ; Ricci JM ; Robins TG ; Walsh MP ; Washington GL ; Wicklund KE
• Corporate Authors:
  Community Action Against Asthma. Steering Committee
• Description:
  Background: Upper respiratory tract viral infections cause asthma exacerbations in children. However, the impact of natural colds on children with asthma in the community, particularly in the high-risk urban environment, is less well defined. Objective: We hypothesized that children with high-symptom upper respiratory viral infections have reduced airway function and greater respiratory tract inflammation than children with virus-positive low-symptom illnesses or virus-negative upper respiratory tract symptoms. Methods: We studied 53 children with asthma from Detroit, Michigan, during scheduled surveillance periods and self-reported respiratory illnesses for 1 year. Symptom score, spirometry, fraction of exhaled nitric oxide (FeNO), and nasal aspirate biomarkers, and viral nucleic acid and rhinovirus (RV) copy number were assessed. Results: Of 658 aspirates collected, 22.9% of surveillance samples and 33.7% of respiratory illnesses were virus-positive. Compared with the virus-negative asymptomatic condition, children with severe colds (symptom score =5) showed reduced forced expiratory flow at 25% to 75% of the pulmonary volume (FEF25%-75%), higher nasal messenger RNA expression of C-X-C motif chemokine ligand (CXCL)-10 and melanoma differentiation-associated protein 5, and higher protein abundance of CXCL8, CXCL10 and C-C motif chemokine ligands (CCL)-2, CCL4, CCL20, and CCL24. Children with mild (symptom score, 1-4) and asymptomatic infections showed normal airway function and fewer biomarker elevations. Virus-negative cold-like illnesses demonstrated increased FeNO, minimal biomarker elevation, and normal airflow. The RV copy number was associated with nasal chemokine levels but not symptom score. Conclusion: Urban children with asthma with high-symptom respiratory viral infections have reduced FEF25%-75% and more elevations of nasal biomarkers than children with mild or symptomatic infections, or virus-negative illnesses. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Biomarkers Occupational Health Respiratory System Safety Viral Diseases
• Keywords:
  Children Nasal Disorders Respiratory Function Viral Infections
• ISSN:
  1081-1206
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  122
• Issue:
  2
• NIOSHTIC Number:
  nn:20055187
• Citation:
  Ann Allergy Asthma Immunol 2019 Feb; 122(2):175-183.e2
• Contact Point Address:
  Marc B. Hershenson, MD, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI 48109-5688
• Email:
  mhershen@umich.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Annals of Allergy, Asthma and Immunology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b83e165a141271e5cfbdd8477062c881ba2bc1e5a8b17f70725769bd47c5f450e09985e5ceac7560e3c4c076ecbfee9ac0b27d826ec519a81d65c668c0ab789d
• Download URL:
  https://stacks.cdc.gov/view/cdc/217545/cdc_217545_DS1.pdf
• File Type:
  [PDF - 734.86 KB ]