Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers

Details

• Personal Author:
  Cervelli J ; Deen M ; Hussain S ; Kipen H ; Laskin DL ; Laskin JD ; Laumbach R ; Radbel J ; Sunderram J ; Sunil VR ; Udasin I ; Vayas KN
• Description:
  Sarcoid-like granulomatous diseases (SGD) have been previously identified in cohorts of World Trade Center (WTC) dust-exposed individuals. In the present studies, we analyzed lung and/or lymph node biopsies from patients referred to our clinic with suspected WTC dust-induced lung disease to evaluate potential pathophysiologic mechanisms. Histologic sections of lung and/or lymph node samples were analyzed for markers of injury, oxidative stress, inflammation, fibrosis, and epigenetic modifications. Out of seven patients examined, we diagnosed four with SGD and two with pulmonary fibrosis; one was diagnosed later with SGD at another medical facility. Patients with SGD were predominantly white, obese men, who were less than 50 years old and never smoked. Cytochrome b5, cytokeratin 17, heme oxygenase-1, lipocalin-2, inducible nitric oxide synthase, cyclooxygenase 2, tumor necrosis factor a, ADP-ribosylation factor-like GTPase 11, mannose receptor-1, galectin-3, transforming growth factor B, histone-3 and methylated histone-3 were identified in lung and lymph nodes at varying levels in all samples examined. Three of the biopsy samples with granulomas displayed peri-granulomatous fibrosis. These findings are important and suggest the potential of WTC dust-induced fibrotic sarcoid. It is likely that patient demographics and/or genetic factors influence the response to WTC dust injury and that these contribute to different pathological outcomes. [Description provided by NIOSH]
• Subjects:
  Aging Demography Dust Emergency Responders Environmental Exposure Fibrosis Genetics Lung Lymphatic System Men Occupational Health Race Factors Respiratory System Risk Assessment Risk Factors Safety September 11 Terrorist Attacks Women

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• Keywords:
  Age Groups Author Keywords: WTC Biopsy Demographic Characteristics Dust Exposure Dusts Emergency Responders Exposure Levels Fibrotic Sarcoid First Responders Genetic Factors Humans Inflammation Injuries Injury Lymph Nodes Oxidative Stress Racial Factors Rescue Workers Risk Factors Sampling World Trade Center WTC

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• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New Jersey ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  5
• NIOSHTIC Number:
  nn:20055069
• Citation:
  Int J Environ Res Public Health 2019 Mar; 16(5):815
• Contact Point Address:
  Vasanthi R. Sunil, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854
• Email:
  sunilva@pharmacy.rutgers.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Piscataway
• Peer Reviewed:
  True
• Start Date:
  20040715
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20111230
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:34b5c7813cd1829c4891c250e562af22126d27c44384d72a6d0bf5c00665ecde1861f0083bb8c3040e51795a668e80d5e23039f867421ad57e52cbd46c2d1bfb
• Download URL:
  https://stacks.cdc.gov/view/cdc/217446/cdc_217446_DS1.pdf
• File Type:
  [PDF - 1.38 MB ]