The Association Between Fine Particulate Matter Chemical Components and Atherosclerosis in the Multi-Ethnic Study of Atherosclerosis

Details

• Personal Author:
  Diez Roux A ; Kaufman JD ; Kim S-Y ; Polak JF ; Sheppard L ; Vedal S
• Description:
  RATIONALE: The association between long-term fine particulate matter (PM2.5) air pollution and subclinical outcomes of atherosclerosis has been reported in previous studies including a study based on the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. There has been increasing interest in identifying PM2.5 chemical components that underlie this association. We examined whether specific PM2.5 chemical components are associated with the extent of common carotid intima-media thickness (CIMT) in the MESA cohort. METHODS: We assessed the association between predicted long-term concentrations of PM2.5 chemical components and right far wall mean thickness of CIMT measured in 5,501 MESA participants residing in six metropolitan U.S. cities (Los Angeles, Chicago, St. Paul, Baltimore, New York, and Winston-Salem) between 2000 to 2002. Long-term PM2.5 component concentrations were predicted at participant homes using a spatio-temporal model based on speciated PM2.5 monitoring data obtained from a dedicated cohort-specific monitoring campaign. We chose four PM2.5 components of particular interest: elemental and organic carbon (EC, OC), sulfur, and silicon as indicators of combustion-generated PM2.5, secondary inorganic aerosol, and crustal dust, respectively. We performed cross-sectional analyses using multiple linear regression to adjust for potential confounders including study city. Our primary model, constructed using a variable selection approach based on previous scientific findings, included age, gender, race/ethnicity, income, education, waist circumstance, body surface area, body mass index, diastolic blood pressure, hypertension, and statin use. RESULTS: Means of predicted long-term concentrations at subject residences of EC, OC, sulfur, and silicon over six cites were 1.43, 2.08, 1.28, and 0.12 ug/m3, respectively. Study participants had a mean age of 62 years, included 52 % females, and were racially diverse. The average CIMT was 0.68 mm. Interquartile increases of 0.65, 0.53, and 0.03 ug/m3 in OC, sulfur, and silicon predictions from the spatio-temporal model were associated with 2.0 % (95% CI=1.2-2.7), 2.5 % (95% CI=1.6-3.4), and 0.6 % (95% CI=0.1-1.1) increases in CIMT, respectively (Table 1). A 0.79 ug/m3 increase in EC was marginally associated with CIMT (0.6 %, 95% CI=0.0-1.3). The associations remained after adjustment for an extended set of covariates, but, with the exception of sulfur, were sensitive to adjustment for study city. CONCLUSIONS: Extent of CIMT was associated with long-term concentrations of OC, silicon and sulfur, and marginally with EC. Our findings suggest that PM2.5 air pollution resulting from some combustion-related sources, secondary inorganic aerosol, and possibly crustal dust may be more likely than PM2.5 from other sources to contribute to atherosclerosis. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Cohort Studies Dust Occupational Health Particulate Matter Safety
• Keywords:
  Air Pollution Cardiovascular Disease Cohort Studies Dust Exposure Health Effects Particulates
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  185
• NIOSHTIC Number:
  nn:20054987
• Citation:
  Am J Respir Crit Care Med 2012 May; 185(Meeting Abstracts):A3193
• Email:
  puha0@uw.edu
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of Washington
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Meeting Abstracts
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bc089ad311995f10a421df95268dfcbc9c048d8f7e624e3402f0096a4780a5d14727899b46af834e4b958884e92c3205361f094f428c9fab0f7f18635b51e38c
• Download URL:
  https://stacks.cdc.gov/view/cdc/217392/cdc_217392_DS1.pdf
• File Type:
  [PDF - 61.16 KB ]