The Effect of Inhaled Multiwalled Carbon Nanotubes on Blood Pressure in Spontaneously Hypertensive Rats

Details

• Personal Author:
  Castranova, Vincent ; Kan H ; Kashon M ; McKinney W ; Zheng W
• Description:
  It is well documented that hypertension is one of the main underlying risk factors for cardiovascular disease and is highly prevalent in the general US population. Considering the large percentage of the population with hypertension and the similarity between the pathogenicity of engineered nanoparticles (ENs) and environmental ultrafine particles, the risk assessment of pulmonary exposure to ENs in subjects with pre-existing hypertension is of great relevance. We reported previously that inhalation of multi-walled carbon nanotubes (MWCNTs) transiently elevated systolic, diastolic and mean blood pressure in rats with normal blood pressure. The present study further investigated the effect of inhaled MWCNTs on spontaneously hypertensive rats. Male normotensive Sprague-Dawley or spontaneously hypertensive Wistar rats were pre-implanted with a telemetry device, and exposed by inhalation to MWCNTs at a concentration of either 5 mg/m3 or 2 mg/m3 for 5h/day for three consecutive days. The electrocardiogram (EKG) and blood pressure were recorded in real time by the telemetry system at pre-exposure, during exposure, and 1 day and 7 days post-exposure. Inhalation of MWCNTs at a concentration of 5 mg/m3 significantly increased both systolic and diastolic blood pressure, and decreased heart rate in normotensive Sprague-Dawley rats during the first day of exposure but these parameters rapidly adapted to continuous exposure. However, inhalation of MWCNTs at a lower concentration of 2 mg/m3 consistently elevated systemic blood pressure for at least 7 days in spontaneously hypertensive Wistar rats. Our study indicates that the blood pressure of spontaneously hypertensive rats is more vulnerable and less tolerant to pulmonary MWCNT exposure. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Electrocardiography Environmental Exposure Laboratories Lung Occupational Health Respiratory System Safety Toxicology
• Keywords:
  Blood Pressure Carbon Nanotubes Cardiovascular Disease Cardiovascular Function CNT Dose Response Exposure Assessment Exposure Levels Heart Disease Heart Rate Hypertension Inhalation Laboratory Animals Laboratory Testing Multi-walled Carbon Nanotubes MWCNT Nanotechnology Nanotoxicology Nanotubes Pulmonary Effects Systolic Pressure

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  168
• Issue:
  1
• NIOSHTIC Number:
  nn:20054963
• Citation:
  Toxicologist 2019 Mar; 168(1):250
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 58th Annual Meeting and ToxExpo, March 10-14, 2019, Baltimore, Maryland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b1807e2e69a3bd49353e171bfa403a6e7f2f1fb8a2b9f369d8da8eb3b52e74e70cdc2818035bbe590688a749a347ad8ee956793c7e7645e8174e276b35084629
• Download URL:
  https://stacks.cdc.gov/view/cdc/217369/cdc_217369_DS1.pdf
• File Type:
  [PDF - 859.45 KB ]