Interaction Between Environmental Tobacco Smoke and Arsenic Methylation Ability on the Risk of Bladder Cancer

Details

• Personal Author:
  Chen Y-C ; Christiani, David C. ; Guo Y-LL ; Houseman EA ; Su H-J
• Description:
  Objective: Arsenic exposure and environmental tobacco smoke (ETS) have been suspected to be associated with bladder cancer risk. We hypothesize that interaction between ETS and the ability to methylate arsenic, a detoxification pathway, modifies the risk of bladder cancer. Methods: From January 1996 to December 1999, we identified 41 newly diagnosed bladder cancer patients and 202 fracture and cataract patients at the National Cheng-Kung University (NCKU) Medical Center. The levels of urinary arsenic species As(III), As(V), MMA(V), and DMA(V) were determined in all subjects. Results: We found significant interaction between ETS and secondary methylation index (SMI) on the risk of bladder cancer (p=0.02). Among non-smokers with a high primary methylation index (PMI), the risk of bladder cancer was lower in subjects exposed to ETS (OR, 0.37; 95% CI, 0.14-0.96) than in subjects without exposure to ETS. Among non-smokers without ETS, the risk of bladder cancer was 4.7 times higher in subjects with a low SMI (95% CI, 1.30-16.81) than in subjects with a high SMI. Conclusions: Ability to methylate arsenic plays an important role in reducing the risk of bladder cancer attributable to the continuation of arsenic exposure from drinking water and from ETS exposure. Description provided by NIOSH
• Subjects:
  • Arsenic
  • Environmental Exposure
  • Inorganic Chemicals
  • Men
  • Neoplasms
  • Occupational Health
  • Risk Assessment
  • Risk Factors
  • Safety
  • Smoke
  More +
• Keywords:
  • Tobacco smoke
  • Environmental exposure
  • Arsenic
  • Exposure levels
  • Risk factors
  • Bladder cancer
  • Cancer
  • Humans
  • Men
  • Women
  More +
• ISSN:
  0957-5243
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  75-81
• Volume:
  16
• Issue:
  2
• NIOSHTIC Number:
  nn:20054960
• Citation:
  Cancer Causes Control 2005 Mar; 16(2):75-81
• Contact Point Address:
  Yen-Ching Chen, Channing Laboratory, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA
• Email:
  karen.chen@channing.harvard.edu
• CAS Registry Number:
  • Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2005
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030701
• Source Full Name:
  Cancer Causes and Control
• End Date:
  20050630
• Download URL:
  https://stacks.cdc.gov/view/cdc/217366/cdc_217366_DS1.pdf
• File Type:
  [PDF - 184.50 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:69ac4961a100b83ef0c05ab1b19d0fe8ca6a18fd9ad8d52adc647c23e0545f5be81861e04cc366b5f453a7cdf2a632f2b601d5e26f97a656523c990420043453