Interaction Between Environmental Tobacco Smoke and Arsenic Methylation Ability on the Risk of Bladder Cancer

Details

• Personal Author:
  Chen Y-C ; Christiani, David C. ; Guo Y-LL ; Houseman EA ; Su H-J
• Description:
  Objective: Arsenic exposure and environmental tobacco smoke (ETS) have been suspected to be associated with bladder cancer risk. We hypothesize that interaction between ETS and the ability to methylate arsenic, a detoxification pathway, modifies the risk of bladder cancer. Methods: From January 1996 to December 1999, we identified 41 newly diagnosed bladder cancer patients and 202 fracture and cataract patients at the National Cheng-Kung University (NCKU) Medical Center. The levels of urinary arsenic species [As(III), As(V), MMA(V), and DMA(V)] were determined in all subjects. Results: We found significant interaction between ETS and secondary methylation index (SMI) on the risk of bladder cancer (p=0.02). Among non-smokers with a high primary methylation index (PMI), the risk of bladder cancer was lower in subjects exposed to ETS (OR, 0.37; 95% CI, 0.14-0.96) than in subjects without exposure to ETS. Among non-smokers without ETS, the risk of bladder cancer was 4.7 times higher in subjects with a low SMI (95% CI, 1.30-16.81) than in subjects with a high SMI. Conclusions: Ability to methylate arsenic plays an important role in reducing the risk of bladder cancer attributable to the continuation of arsenic exposure from drinking water and from ETS exposure. [Description provided by NIOSH]
• Subjects:
  Arsenic Environmental Exposure Inorganic Chemicals Men Neoplasms Occupational Health Risk Assessment Risk Factors Safety Smoke Tobacco Products Urine Women

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• Keywords:
  Author Keywords: Arsenic Methylation Ability Bladder Cancer Cancer Environmental Exposure Environmental Tobacco Smoke Exposure Levels Humans Risk Factors Statistical Analysis Taiwan Tobacco Smoke Urinalysis

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• ISSN:
  0957-5243
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  75-81
• Volume:
  16
• Issue:
  2
• NIOSHTIC Number:
  nn:20054960
• Citation:
  Cancer Causes Control 2005 Mar; 16(2):75-81
• Contact Point Address:
  Yen-Ching Chen, Channing Laboratory, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA
• Email:
  karen.chen@channing.harvard.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2005
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030701
• Source Full Name:
  Cancer Causes and Control
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:69ac4961a100b83ef0c05ab1b19d0fe8ca6a18fd9ad8d52adc647c23e0545f5be81861e04cc366b5f453a7cdf2a632f2b601d5e26f97a656523c990420043453
• Download URL:
  https://stacks.cdc.gov/view/cdc/217366/cdc_217366_DS1.pdf
• File Type:
  [PDF - 184.50 KB ]