Arsenic Methylation and Bladder Cancer Risk in Taiwan

Details

• Personal Author:
  Chen Y-C ; Christiani, David C. ; Guo Y-LL ; Hsueh Y-M ; Lee M-S ; Ryan LM ; Smith, Thomas J. ; Su H-JJ
• Description:
  OBJECTIVE: The mechanism of arsenic detoxification in humans remains unclear. Data are especially lacking for low-level arsenic exposure. We hypothesize that arsenic methylation ability, defined as the ratios of monomethylarsonic acid (MMA(V))/inorganic arsenic (primary arsenic methylation index, PMI) and dimethylarsinic acid (DMA(V))/ MMA(V) (secondary arsenic methylation index, SMI), may modify the association between cumulative arsenic exposure (CAE, mg/L-year) and the risk of bladder cancer. In this study we investigated the relationship among arsenic methylation ability, CAE, and the risk of bladder cancer in a hospital-based case-control study in southwestern Taiwan. METHODS: From January 1996 to December 1999 we identified 49 patients with newly diagnosed cases of bladder cancer at the National Cheng-Kung University (NCKU) Medical Center; controls consisted of 224 fracture and cataract patients selected from the same medical center. The levels of four urinary arsenic species: arsenite (As(III)), arsenate (As(V)), MMA(V), and DMA(V)) were determined in all subjects by using the high-performance liquid chromatography hydride-generation atomic absorption spectrometry (HPLC-HGAAS). CAE was estimated by using published data collected in a survey from 1974 to 1976. RESULTS: Compared to a CAE < or = 2 mg/L-year, CAE > 12 mg/L-year was associated with an increased risk of bladder cancer (multivariate odds ratio (OR) 4.23, 95% confidence interval (CI) 1.12-16.01), in the setting of a low SMI (< or = 4.8). Compared to women, smoking men (OR 6.23, 95% CI 1.88-20.62) and non-smoking men (OR 3.25, 95% CI 0.95-11.06) had higher risks of bladder cancer. Given the same level of PMI, smoking men (OR 9.80, 95% CI 2.40-40.10) and non-smoking men (OR 4.45, 95% CI 1.00-19.84) had a higher risk of bladder cancer when compared to women. With the same level of SMI, both smoking men (OR 6.28, 95% CI 1.76-22.39) and non-smoking men (OR 3.31, 95% CI 0.84-12.97) had a higher risk of bladder cancer when compared to women. CONCLUSIONS: Subjects with low SMI have a substantially increased risk of bladder cancer, especially when combined with high CAE levels. [Description provided by NIOSH]
• Subjects:
  Aging Arsenic Energy Metabolism Environmental Exposure Epidemiology Inorganic Chemicals Men Occupational Health Risk Assessment Risk Factors Safety Smokers Urine Women

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• Keywords:
  Age Groups Arsenates Arsenites Author Keywords: Arsenic Methylation Ability Bladder Cancer Chemicals Cumulative Arsenic Exposure Detoxification Dimethylarsinic Acid Exposure Levels Humans Liquid Chromatography Metabolism Risk Factors Smoking Taiwan Urinalysis

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• ISSN:
  0957-5243
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  303-310
• Volume:
  14
• Issue:
  4
• NIOSHTIC Number:
  nn:20054570
• Citation:
  Cancer Causes Control 2003 May; 14(4):303-310
• Contact Point Address:
  David C. Christiani, Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
• Email:
  chris@hohp.harvard.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2003
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030731
• Source Full Name:
  Cancer Causes and Control
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dadbf173b01edb89d9fb9f5447e9e3080918ae89d5d9dd313af6522c94f6ef9c3c2bd9c5ca7fad389d8d6c0689ba0deb7f2171739b0e2802b04688d23fee245
• Download URL:
  https://stacks.cdc.gov/view/cdc/217094/cdc_217094_DS1.pdf
• File Type:
  [PDF - 215.39 KB ]