Personal Coronary Risk Profiles Modify Autonomic Nervous System Responses to Air Pollution

Details

• Personal Author:
  Chen J-C ; Christiani, David C. ; Herrick, Robert F. ; Kim J-Y ; MacCallum G ; Nearing BD ; Stone PH ; Verrier RL ; You J ; Zhou H
• Description:
  Objective: We investigated whether PM2.5-mediated autonomic modulation depends on individual coronary risk profiles. Methods: Five-minute average heart rate (HR) and heart rate variability (HRV, including standard deviation of normal-to-normal intervals [SDNN], square root of the mean squared differences of successive NN intervals [rMSSD], high frequency [HF]) were measured from 24-hour ambulatory electrocardiograms, and personal PM2.5 exposures were monitored in a prospective study of 10 male boilermakers (aged 34.3 +/- 8.1 years). We used the Framingham score to classify individuals into low (score = 1-3) and high (score = 5-6) risk categories. Mixed-effect models were used for statistical analyses. Results: Each 1-mg/m3 increase in the preceding 4-hour moving average PM2.5 was associated with HR increase (5.3 beats/min) and HRV reduction (11.7%, confidence interval [CI] = 6.2-17.1% for SDNN; 11.1%, CI = 3.1-19.1% for rMSSD; 16.6%, CI = 1.5-31.7% for HF). Greater responses (2- to 4-fold differences) were observed in high-risk subjects than in low-risk subjects. Conclusions: Our study suggests that adverse autonomic responses to metal particulate are aggravated in workers with higher coronary risk profiles. [Description provided by NIOSH]
• Subjects:
  Aging Cardiovascular System Electrocardiography Environmental Exposure Men Metals Occupational Health Particulate Matter Safety
• Keywords:
  Age Groups Exposure Levels Heart Heart Rate Humans Metal Compounds Metallic Compounds Models Particulates Statistical Analysis
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  48
• Issue:
  11
• NIOSHTIC Number:
  nn:20054946
• Citation:
  J Occup Environ Med 2006 Nov; 48(11):1133-1142
• Contact Point Address:
  David C. Christiani, MD, MPH, MS, Harvard School of Public Health, Rm. 1402, HSPH-1, 655 Huntington Avenue, Boston, MA 02115
• Email:
  dchristi@hsph.harvard.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b669d31ad438a0d3f20a1bb14901d7a22744a5d31fef85f53e0086aff3ee68429b0d058c26918ed6cefc31316ae37c3bff3b4643bbeb3ee63619d295f76eeaa0
• Download URL:
  https://stacks.cdc.gov/view/cdc/217352/cdc_217352_DS1.pdf
• File Type:
  [PDF - 230.02 KB ]