Time Course of Heart Rate Variability Decline Following Particulate Matter Exposures in an Occupational Cohort

Details

• Personal Author:
  Cavallari JM ; Christiani, David C. ; Eisen EA ; Fang SC ; Hauser R ; Herrick, Robert F. ; Schwartz J
• Description:
  Although research suggests that particles influence cardiac autonomic response as evidenced by decreases in heart rate variability (HRV), the time course of the response remains unclear. Using a crossover panel study, we monitored 36 male boilermaker welders, occupationally exposed to metal-rich particulate matter (PM) to investigate the temporal trend of hourly HRV subsequent to PM exposure. Ambulatory electrocardiograms were collected over work (exposure) and non-work (control) periods and the mean of the standard deviations of all normal-to-normal intervals for all 5-min segments (SDNN(i)) was calculated hourly for up to 14-hrs post-work. The exposure-response relationship was examined with linear mixed effects regression models to account for participants monitored over multiple occasions. Models were adjusted for non-work HRV to control for diurnal fluctuations and individual predictors of HRV. The mean (SD) work PM(2. 5) concentration was 1.12 (0.76) mg/m(3). Hourly SDNN(i) was consistently lower post-work as compared to the same time period on a non-work day. HRV was inversely associated with work PM(2. 5) exposures in each of the 14-hrs post-work. The hourly associations suggested an early and later phase response, with the largest regression coefficients observed 2-3 hrs (beta = -6.86 (95% CI: -11.91, -1.81) msec/1 mg/m(3) at 3-hrs), and then 9-13 hrs (beta = -8.60 (95% CI: -17.45, 0.24) msec/1 mg/m(3) at 11-hrs), after adjusting for non-work HRV, smoking status, and age. This investigation demonstrates declines in HRV for up to 14 hours following PM exposure and a multiphase cardiovascular autonomic response with immediate (2 hrs) and delayed (9-13 hrs) responses. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Cardiovascular Diseases Cardiovascular System Electrocardiography Environmental Exposure Men Metals Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Welding

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• Keywords:
  Air Pollutants Cardiovascular System Cardiovascular System Disease Drugs Exposure Levels Health Effects Heart Heart Disease Heart Rate Humans Metal Compounds Metallic Compounds Metallurgy Models Monitors Particulates Risk Factors Welders

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• ISSN:
  0895-8378
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  415-422
• Volume:
  20
• Issue:
  4
• NIOSHTIC Number:
  nn:20054476
• Citation:
  Inhal Toxicol 2008 Mar; 20(4):415-422
• Contact Point Address:
  Jennifer M. Cavallari, ScD, CIH, Harvard School of Public Health, Environmental and Occupational Medicine and Epidemiology Program, 665 Huntington Ave., SPH1-1420, Boston, MA 02115
• Email:
  jcavalla@hsph.harvard.edu
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Inhalation Toxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c400c5048d49b66cf45ed9ca6805000123fbcd57b0f967be1344b559fa87fb5d6f212dffd2d854b04138791ad29f4f240a5eb8d2aa94d5a3c6c69f7cf2350767
• Download URL:
  https://stacks.cdc.gov/view/cdc/217033/cdc_217033_DS1.pdf
• File Type:
  [PDF - 89.85 KB ]