Neuromotor Effects of Manganese Exposure in Adolescents Entering Workforce

Details

• Personal Author:
  Bhattacharya, Amit ; Cox, Clinton ; Haynes EN ; McBride D ; Sucharew H
• Description:
  BACKGROUND: Manganese (Mn) is an essential nutrient, yet neurotoxic in excess. Mn can negatively impact neuromotor function. Adolescence is a critical time of development, as many begin to enter the labor force for the first time. Marietta, Ohio is home to America's largest ferromanganese refinery, a significant source of ambient Mn. In this community-based longitudinal cohort study, we investigate the relationship between adolescent exposure to manganese and neuromotor function. METHODS: Recruitment Criteria: Mother resided in community since 16th week pregnancy, child initial enrollment at 7-9 yrs; age at balance testing 13-17 yrs; Covariates: Age, sex, height to weight ratio, parent IQ, parent education, serum cotinine; Biological Measures: Blood Mn, Pb; Hair Mn; Neuromotor Measurement: Postural Balance; Gait. EXPECTED RESULTS: Given the role of Mn as both essential and neurotoxic, we expect to find a biphasic relationship between biomarkers of Mn exposure and adolescent neuromotor function, as measured by postural balance and gait. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Environmental Exposure Manganese Nervous System Occupational Health Safety
• Keywords:
  Children Cohort Studies Exposure Levels Longitudinal Study Neuromotor Function Neurotoxic Agents
• Publisher:
  University of Cincinnati
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1
• NIOSHTIC Number:
  nn:20054918
• Citation:
  19th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 11-12, 2018, Cincinnati, Ohio. Cincinnati, OH: University of Cincinnati, 2018 Oct; :1
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  19th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 11-12, 2018, Cincinnati, Ohio
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:be7bed7618cf2a34f934b11d1d2315aed4207dc0a39492227f07b49fbada8d08f4d0755fa8e07c0e9fae5779fdbf5c22956ea124a65049cffee3cbc2c34c54ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/217328/cdc_217328_DS1.pdf
• File Type:
  [PDF - 134.80 KB ]