An Update on the Multiethnic Study of Atherosclerosis and Air Pollution

Details

• Personal Author:
  Kaufman J
• Description:
  Background/Aims: "MESA Air" (Multi-Ethnic Study of Atherosclerosis and Air Pollution) is a multicenter prospective cohort study of air pollution and cardiovascular disease (CVD) launched in 2004, combining state-of-the-art cardiovascular outcome measurements with individual-level exposure assessment. The central hypothesis is that long-term exposure to airborne fine particulate matter is associated with accelerated atherosclerosis and risk of clinical cardiovascular events. Methods: MESA Air builds on the framework of the National Heart, Lung, and Blood Institute multiethnic study of atherosclerosis (MESA). MESA studies risk factors (and evidence of pre-clinical processes) that predict development of clinical CVD among individuals without known CVD, in a population-based sample from 6 major metropolitan areas. MESA Air adds to MESA individual-level exposure estimates that integrate spatio-temporal modeling of outdoor air concentrations, participant-specific predictions of residential pollutant infiltration efficiency, and time-location patterns. MESA Air supports a follow-up measurement of intima-medial thickness of the carotid artery and coronary artery calcification (CT scan) in 3600 participants in an examination now underway. Annual follow-up of each participant (n > 6000) is followed by medical record review. Individual exposure estimates will be combined with each participant's cardiovascular status to understand the influence of air pollution exposure on progression of CVD. Results: MESA Air is halfway through its 10-year project period; analysis of primary study outcomes will not proceed until 2012. However, progress to date is notable: Advances in exposure modeling approaches will be reviewed. Initial epidemiologic analyses demonstrate associations between predicted outdoor air pollutant concentrations at participants' homes and extent of emphysema (CT scan), microvascular phenomena (retinal photography), and left ventricular mass (MRI). Conclusion: MESA Air is a comprehensive epidemiologic study of long-term air pollution exposures and CVD. This research will provide refined estimates of risks associated with exposure to air pollution and stimulate hypotheses regarding biologic mechanisms. The presentation will provide analysis updates and opportunities for collaboration. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Cohort Studies Epidemiology Occupational Exposure Occupational Health Particulate Matter Risk Assessment Risk Factors Safety

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• Keywords:
  Air Pollution Cardiovascular Disease Chronic Exposure Cohort Studies Health Effects Particulates Risk Factors
• ISSN:
  1044-3983
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  1
• NIOSHTIC Number:
  nn:20054895
• Citation:
  Epidemiology 2011 Jan; 22(1)(Jan Suppl 2011):S226-S227
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Washington
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Epidemiology
• Supplement:
  Jan Suppl 2011
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:467a815603e713550e2fe84f820852c7d3540e9cc6802d0ff1fdc5f9872b42a84663029f96dd5400f45342987cbde8aeced26e66e5bc751269338247bf4d00f6
• Download URL:
  https://stacks.cdc.gov/view/cdc/217308/cdc_217308_DS1.pdf
• File Type:
  [PDF - 57.79 KB ]