Ambient Particulate Matter Exposure and Hypertension Incidence in the Multiethnic Study of Atherosclerosis

Details

• Personal Author:
  Adar S ; Auchincloss A ; Chen Y-H ; Daviglus M ; Diez-Roux A ; Kaufman J ; O'Neill M ; Park SK ; Szpiro A
• Description:
  Background/Aims: Despite evidence of a cross-sectional association between ambient fine particulate matter (PM2.5) and high blood pressure, no population-based study has explored the association of fine particle exposure with incident hypertension. This study examined whether ambient PM2.5 is associated with hypertension incidence. Methods: The study included 3006 participants, aged 45-84 years and without hypertension (systolic blood pressure =140 mm Hg, diastolic blood pressure =90 mm Hg, or on antihypertensive medications) at the baseline examination (2000-2002) of the Multiethnic Study of Atherosclerosis. Annual average PM2.5 concentrations at participant residences were calculated for 2001 using a spatio-temporal model and used as a proxy for exposure over the 5-year follow-up period. Incident hypertension was defined by participant's SBP = 140 mm Hg, DBP = 90 mm Hg, or on antihypertensive medications at follow-up visits. Hazard ratios of incident hypertension per 10 ug/m3 increment in PM2.5 were estimated using interval censored survival analysis, adjusting for age, sex, race/ethnicity, systolic blood pressure, diastolic blood pressure, body mass index, diabetes, smoking, passive smoking, alcohol use, healthy diet index, and physical activity at baseline. Results: A total of 825 new cases of hypertension occurred over the 5-year follow-up. The mean estimated PM2.5 exposure was 17.3 ug/m3 (standard deviation, 3.2 ug/m3). For each 10 ug/m3 increment of PM2.5, the adjusted hazard ratio for incident hypertension was 1.22 (95% confidence interval, 0.93-1.59). The point estimate of association remained positive and not statistically significant after further adjustment for study site and socioeconomic status (income and education) at baseline. Conclusion: Results from our study sample provide only weak support to the hypothesis that exposure to ambient fine particulate air pollution may contribute to onset of hypertension. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Cohort Studies Epidemiology Occupational Health Particulate Matter Risk Assessment Risk Factors Safety
• Keywords:
  Air Pollution Blood Pressure Cohort Studies Health Effects Hypertension Particulates Risk Factors
• ISSN:
  1044-3983
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Illinois ; Michigan ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  1
• NIOSHTIC Number:
  nn:20054894
• Citation:
  Epidemiology 2011 Jan; 22(1)(Jan Suppl 2011):S198
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Washington
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Epidemiology
• Supplement:
  Jan Suppl 2011
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3e3702e2ef48d090cacf018e8faddead2c653d77cd5be34dc20e7eea4f617cea5956080497f4b53385e7acda0aba08ca24315341ba1e894c1bbf9a27b3da97d1
• Download URL:
  https://stacks.cdc.gov/view/cdc/217307/cdc_217307_DS1.pdf
• File Type:
  [PDF - 48.88 KB ]