Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2002.131257
Personal Author:
Mikosz, Christina A. ; Smith, Rachel M. ; Kim, Moon ; Tyson, Clara ; Lee, Ellen H. ; ... More +
Mikosz, Christina A. ; Smith, Rachel M. ; Kim, Moon ; Tyson, Clara ; Lee, Ellen H. ; Adams, Eleanor ; Straif-Bourgeois, Susanne ; Sowadsky, Rick ; Arroyo, Shannon ; Grant-Greene, Yoran ; Duran, Julie ; Vasquez, Yvonne ; Robinson, Byron F. ; Harris, Julie R. ; Lockhart, Shawn R. ; Török, Thomas J. ; Mascola, Laurene ; Park, Benjamin J. Less -
Corporate Authors:
for the Fungal Endophthalmitis Outbreak Response Team
Description:
Fungal endophthalmitis is a rare but serious infection. In March 2012, several cases of probable and laboratory-confirmed fungal endophthalmitis occurring after invasive ocular procedures were reported nationwide. We identified 47 cases in 9 states: 21 patients had been exposed to the intraocular dye Brilliant Blue G (BBG) during retinal surgery, and the other 26 had received an intravitreal injection containing triamcinolone acetonide. Both drugs were produced by Franck's Compounding Lab (Ocala, FL, USA). Fusarium incarnatum-equiseti species complex mold was identified in specimens from BBG-exposed case-patients and an unopened BBG vial. Bipolaris hawaiiensis mold was identified in specimens from triamcinolone-exposed case-patients. Exposure to either product was the only factor associated with case status. Of 40 case-patients for whom data were available, 39 (98%) lost vision. These concurrent outbreaks, associated with 1 compounding pharmacy, resulted in a product recall. Ensuring safety and integrity of compounded medications is critical for preventing further outbreaks associated with compounded products.
Subject:
[+]
Aged
Aged, 80 And Over
Blindness
Drug Recalls
Endophthalmitis
Eye Infections, Fungal
Female
Fusarium
Humans
Male
Middle Aged
Ophthalmic Solutions
Retina
Rosaniline Dyes
Saccharomycetales
Triamcinolone Acetonide
Vitreous Body

Source:
Emerg Infect Dis. 20(2):248-256.
Document Type:
Journal Article
Place as Subject:
United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:0ef849b160f05b2325077033c5905bce6f8bca8f7b942cc731557684b19b6b25
File Type:

Supporting Files

• 	13-1257-F1.gif	gif
  	13-1257-F1.jpg	jpeg
  	13-1257-F2.gif	gif
  	13-1257-F2.jpg	jpeg
  	13-1257.nxml	txt
  	license.txt	txt

More +