Fungal Endophthalmitis Associated with Compounded Products

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Mikosz, Christina A. ; Smith, Rachel M. ; Kim, Moon ; Tyson, Clara ; Lee, Ellen H. ; Adams, Eleanor ; Straif-Bourgeois, Susanne ; Sowadsky, Rick ; Arroyo, Shannon ; Grant-Greene, Yoran ; Duran, Julie ; Vasquez, Yvonne ; Robinson, Byron F. ; Harris, Julie R. ; Lockhart, Shawn R. ; Török, Thomas J. ; Mascola, Laurene ; Park, Benjamin J.
• Corporate Authors:
  for the Fungal Endophthalmitis Outbreak Response Team
• Description:
  Fungal endophthalmitis is a rare but serious infection. In March 2012, several cases of probable and laboratory-confirmed fungal endophthalmitis occurring after invasive ocular procedures were reported nationwide. We identified 47 cases in 9 states: 21 patients had been exposed to the intraocular dye Brilliant Blue G (BBG) during retinal surgery, and the other 26 had received an intravitreal injection containing triamcinolone acetonide. Both drugs were produced by Franck's Compounding Lab (Ocala, FL, USA). Fusarium incarnatum-equiseti species complex mold was identified in specimens from BBG-exposed case-patients and an unopened BBG vial. Bipolaris hawaiiensis mold was identified in specimens from triamcinolone-exposed case-patients. Exposure to either product was the only factor associated with case status. Of 40 case-patients for whom data were available, 39 (98%) lost vision. These concurrent outbreaks, associated with 1 compounding pharmacy, resulted in a product recall. Ensuring safety and integrity of compounded medications is critical for preventing further outbreaks associated with compounded products.
• Subjects:
  Aged Aged, 80 And Over Blindness Drug Recalls Endophthalmitis Eye Infections, Fungal Female Fusarium Humans Male Middle Aged Ophthalmic Solutions Retina Rosaniline Dyes Saccharomycetales Triamcinolone Acetonide Vitreous Body

  More +
• Source:
  Emerg Infect Dis. 20(2):248-256.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  20
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0ef849b160f05b2325077033c5905bce6f8bca8f7b942cc731557684b19b6b25
• Download URL:
  https://stacks.cdc.gov/view/cdc/21729/cdc_21729_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]