Mouse Pulmonary Response Induced by Exposure to Dust from Sawing Corian, a Solid-Surface Composite Material

Details

• Personal Author:
  Battelli L ; Bowers L ; Knepp A ; Mandler W ; Mercer R ; Orandle M ; Qi C ; Qian Y ; Sarkisian K ; Sisler J ; Stefaniak, Aleksandr B.
• Description:
  Corian, a solid-surface composite (SSC), is composed of a proprietary blend of powdered alumina trihydrate, methyl methacrylate, and other binders and colorants. The present study evaluated the murine pulmonary toxicity from exposure to dust generated from sawing of SSC. The particle number-based geometric mean diameter and geometric standard deviation sigmag of the airborne fraction SSC sawing dust following suspension in saline was 1.16 microm, sigmag = 2.18, which is similar to the number-based geometric mean aerodynamic diameter to aerosolized SSC sawing dust of 1.05 microm, sigmag = 1.78. Inductively coupled plasma and energy dispersive X-ray spectroscopy analyses confirmed that aluminum was the principle inorganic component of SSC sawing dust (29.7 6 +/- 1.3%) and was not different compared to airborne SSC. Mice were exposed to 62.5, 125, 250, 500, or 1000 microg of SSC dust, saline, or 1000 microg silica positive control via oropharyngeal aspiration. At 1 and 14 days post-expsoure, the body weights of both 500 and 1000 microg group mice were signifcantly lower than those of the saline group. Analysis of brochoalveolar lavage fluid showed that lactate dehydrogenase, inflammatory cells, and pro-inflammatory cytokines were elevated in the 500 and 1000 microg SSC exposure groups at days 1 and 14 post-exposure, indicating that exposue to the SSC sawing dust induced an inflammatory response in mice. Furthermore, lung histopathology indicated inflammation in alveoli at all doses at day 1 post-exposure, and fibrosis in the 1000 microg dose at day 14 post-exposure. Darkfield imaging indicated alveolar particle deposition and granulomatous mass formation persisting to 14 days post-exposure in all exposure groups. Taken together, these findings suggest that SSC sawing dust exposure may induce pulmonary inflammation and damage that warrants further investigation. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Body Weight Dust Environmental Exposure Immune System Laboratories Lung Lung Diseases Occupational Health Particulate Matter Radiography Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide Spectrum Analysis Toxicology

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• Keywords:
  Airborne Dusts Airborne Particles Alveolar Cells Ammonia Compounds Body Weight Cytokines Dose Response Dust Exposure Exposure Assessment Exposure Levels Histopathology Immune Reaction Inhalation Laboratory Animals Laboratory Testing Lung Cells Lung Fibrosis Methyl Compounds Methyl Methacrylate Particle Diameter Particle Size Pulmonary Effects Silica Silica Dusts Spectrographic Analysis X-ray Analysis

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DART - Division of Applied Research and Technology ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  21
• Volume:
  168
• Issue:
  1
• NIOSHTIC Number:
  nn:20054872
• Citation:
  Toxicologist 2019 Mar; 168(1):21
• CAS Registry Number:
  2-Propenoic acid, 2-methyl-, methyl ester (CAS RN 80-62-6) ; Aluminum (CAS RN 7429-90-5) ; Aluminum hydroxide (CAS RN 21645-51-2) ; Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Manufacturing ; Construction
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 58th Annual Meeting and ToxExpo, March 10-14, 2019, Baltimore, Maryland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9ee3b77771fdf5d1b10248afeea583ac212d9c82d565f879db4c79f8a4304b235ed3a0f243e11df66fa1e9f40d21496348a5d26840390d930452c303c2b2b37d
• Download URL:
  https://stacks.cdc.gov/view/cdc/217287/cdc_217287_DS1.pdf
• File Type:
  [PDF - 859.74 KB ]