Mouse Pulmonary Response to Dust from Sawing Corian®, a Solid-Surface Composite Material

Details

• Personal Author:
  Battelli LA ; Bowers LN ; Friend SA ; Knepp AK ; Mandler WK ; Mercer RR ; Orandle MS ; Qi C ; Qian Y ; Sarkisian K ; Shaffer J ; Sisler JD ; Stefaniak, Aleksandr B.
• Description:
  Corian, a solid-surface composite (SSC), is composed of alumina trihydrate and acrylic polymer. The aim of the present study was to examine the pulmonary toxicity attributed to exposure to SSC sawing dust. Male mice were exposed to either phosphate buffer saline (PBS, control), 62.5, 125, 250, 500, or 1000 ug of SSC dust, or 1000 µg silica (positive control) via oropharyngeal aspiration. Body weights were measured for the duration of the study. Bronchoalveolar lavage fluid (BALF) and tissues were collected for analysis at 1 and 14 days post-exposure. Enhanced-darkfield and histopathologic analysis was performed to assess particle distribution and inflammatory responses. BALF cells and inflammatory cytokines were measured. The geometric mean diameter of SSC sawing dust following suspension in PBS was 1.25 um. BALF analysis indicated that lactate dehydrogenase (LDH) activity, inflammatory cells, and pro-inflammatory cytokines were significantly elevated in the 500 and 1000 µg SSC exposure groups at days 1 and 14, suggesting that exposure to these concentrations of SSC induced inflammatory responses, in some cases to a greater degree than the silica positive control. Histopathology indicated the presence of acute alveolitis at all doses at day 1, which was largely resolved by day 14. Alveolar particle deposition and granulomatous mass formation were observed in all exposure groups at day 14. The SSC particles were poorly cleared, with 81% remaining at the end of the observation period. These findings demonstrate that SSC sawing dust exposure induces pulmonary inflammation and damage that warrants further investigation. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Body Weight Dust Environmental Exposure Immune System Laboratories Lung Lung Diseases Occupational Health Particulate Matter Radiography Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide Spectrum Analysis Toxicology

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• Keywords:
  Airborne Dusts Airborne Particles Alveolar Cells Ammonia Compounds Author Keywords: Particle Toxicity Body Weight Composites Cytokines Dose Response Dust Exposure Exposure Assessment Exposure Levels Histopathology Immune Reaction Inhalation Laboratory Animals Laboratory Testing Lung Cells Lung Fibrosis Methyl Compounds Methyl Methacrylate Particle Diameter Particle Size Pulmonary Effects Pulmonary Injury Risk Assessment Silica Silica Dusts Spectrographic Analysis X-ray Analysis

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• ISSN:
  1528-7394
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DART - Division of Applied Research and Technology ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  82
• Issue:
  11
• NIOSHTIC Number:
  nn:20056574
• Citation:
  J Toxicol Environ Health A 2019 Jun; 82(11):643-663
• CAS Registry Number:
  Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Manufacturing ; Healthcare and Social Assistance
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fee0240d87afec143e61e29f7070a054b28af377eea6d105ce522e85e3d90cf424ac13a30d8391d08d9ba8da2c539287336a3cdb0c5deb6a01155fe0c4541a19
• Download URL:
  https://stacks.cdc.gov/view/cdc/214157/cdc_214157_DS1.pdf
• File Type:
  [PDF - 3.17 MB ]