Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children

Biesbroek, Giske; Wang, Xinhui; Keijser, Bart J.F.; Eijkemans, Rene M.J.; Trzciński, Krzysztof; Rots, Nynke Y.; Veenhoven, Reinier H.; Sanders, Elisabeth A.M.; Bogaert, Debby

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Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children

Supporting Files Public Domain

Feb 2014
By Biesbroek, Giske ; Wang, Xinhui ; Keijser, Bart J.F. ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Biesbroek, Giske ; Wang, Xinhui ; Keijser, Bart J.F. ; Eijkemans, Rene M.J. ; Trzciński, Krzysztof ; Rots, Nynke Y. ; Veenhoven, Reinier H. ; Sanders, Elisabeth A.M. ; Bogaert, Debby
Description:

Seven-valent pneumococcal conjugate vaccine (PCV-7) is effective against vaccine serotype disease and carriage. Nevertheless, shifts in colonization and disease toward nonvaccine serotypes and other potential pathogens have been described. To understand the extent of these shifts, we analyzed nasopharyngeal microbial profiles of 97 PCV-7-vaccinated infants and 103 control infants participating in a randomized controlled trial in the Netherlands. PCV-7 immunization resulted in a temporary shift in microbial community composition and increased bacterial diversity. Immunization also resulted in decreased presence of the pneumococcal vaccine serotype and an increase in the relative abundance and presence of nonpneumococcal streptococci and anaerobic bacteria. Furthermore, the abundance of Haemophilus and Staphylococcus bacteria in vaccinees was increased over that in controls. This study illustrates the much broader effect of vaccination with PCV-7 on the microbial community than currently assumed, and highlights the need for careful monitoring when implementing vaccines directed against common colonizers.
Subjects:

Bacteria Children Colonization Nasopharyngeal Microbiota PCV-7 Pneumococcal Conjugate Vaccination Pneumococcal Conjugate Vaccine Pneumococci Randomized Controlled Trial Research Respiratory Tract
Source:

Emerg Infect Dis. 20(2):201-210.
Document Type:

Journal Article
Volume:

20
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:43827105d1f0e2e070eb796861dbaddf16f5ede086afb9e81ae8f67ca7dcbf40
Download URL:

https://stacks.cdc.gov/view/cdc/21727/cdc_21727_DS1.pdf
File Type:

[PDF - 821.56 KB ]

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