Quantitative Neuropathology Associated with Chronic Manganese Exposure in South African Mine Workers

Details

• Personal Author:
  Checkoway, Harvey ; Criswell SR ; Evanoff BA ; Gelman BB ; Gonzalez-Cuyar LF ; Ho P ; Lonzanida JA ; Murray J ; Nelson G ; Racette BA ; Seixas, Noah S. ; Zhang J
• Description:
  Manganese (Mn) is a common neurotoxicant associated with a clinical syndrome that includes signs and symptoms referable to the basal ganglia. Despite many advances in understanding the pathophysiology of Mn neurotoxicity in humans, with molecular and structural imaging techniques, only a few case reports describe the associated pathological findings, and all are in symptomatic subjects exposed to relatively high-level Mn. We performed an exploratory, neurohistopathological study to investigate the changes in the corpus striatum (caudate nucleus, putamen, and globus pallidus) associated with chronic low-level Mn exposure in South African Mn mine workers. Immunohistochemical techniques were used to quantify cell density of neuronal and glial components of the corpus striatum in eight South African Mn mine workers without clinical evidence of a movement disorder and eight age-race-gender matched, non-Mn mine workers. There was higher mean microglia density in Mn mine workers than non-Mn mine workers in the globus pallidus external and internal segments [GPe: 1.33 and 0.87 cells per HPF, respectively (p = 0.064); GPi: 1.37 and 0.99 cells per HPF, respectively (p = 0.250)]. The number of years worked in the Mn mines was significantly correlated with microglial density in the GPi (Spearman's rho 0.886; p = 0.019). The ratio of astrocytes to microglia in each brain region was lower in the Mn mine workers than the non-Mn mine workers in the caudate (7.80 and 14.68; p = 0.025), putamen (7.35 and 11.11; p = 0.117), GPe (10.60 and 16.10; p = 0.091) and GPi (9.56 and 12.42; p = 0.376). Future studies incorporating more detailed occupational exposures in a larger sample of Mn mine workers will be needed to demonstrate an etiologic relationship between Mn exposure and these pathological findings. [Description provided by NIOSH]
• Subjects:
  Manganese Mining Nervous System Occupational Exposure Occupational Health Safety
• Keywords:
  Astrocytes Author Keywords: Neuropathology Biological Effects Central Nervous System Corpus Striatum Microglia Mine Workers Neurodegeneration Neurological System Neurotoxic Effects Neurotoxicity Occupational Exposure

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• ISSN:
  0161-813X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Missouri ; OSHA Region 10 ; OSHA Region 6 ; OSHA Region 7 ; OSHA Region 9 ; Texas ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  260-266
• Volume:
  45
• NIOSHTIC Number:
  nn:20054774
• Citation:
  Neurotoxicology 2014 Dec; 45:260-266
• Contact Point Address:
  Brad A. Racette, Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, Saint Louis, MO 63110, USA
• Email:
  racetteb@neuro.wustl.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Neurotoxicology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:38f3ad413fbea98fbd1faf131facfa4d821a449b2140718875e98f14e3f5098e0ee797b963fad1e96b57c3e5378dfd249cea722215ba3b8fccd35b345fe91c91
• Download URL:
  https://stacks.cdc.gov/view/cdc/217207/cdc_217207_DS1.pdf
• File Type:
  [PDF - 719.24 KB ]