Evaluation of Urinary Metabolites of 1-Nitropyrene as Biomarkers for Exposure to Diesel Exhaust in Taxi Drivers of Shenyang, China

Details

• Personal Author:
  Dong L ; Hayakawa K ; Kameda T ; Miller-Schulze JP ; Paulsen M ; Simpson CD ; Tamura K ; Tang N ; Toriba A ; Yost MG ; Zhang X
• Description:
  Diesel exhaust (DE) is a significant contributor to the toxicity associated with particulate matter (PM). 1-Nitropyrene (1-NP) has been used as a molecular marker for DE, and the urinary metabolites of 1-NP have been proposed as biomarkers for exposure to DE. In this study, several urinary 1-NP metabolites were evaluated for their utility as markers of short-term exposures to DE. The study population was a cohort of 24 taxi drivers from Shenyang, China, who submitted urine samples collected before, after, and the next morning following their workshifts. The urinary metabolites studied were isomers of hydroxy-1-nitropyrene (3-, 6-, 8- OHNPs) and hydroxy-N-acetyl-1-aminopyrene (3-,6-, 8-OHNAAPs). Exposure to DE was estimated based on exposure to 1-NP in air samples collected during and after the driver's workshift; 6- and 8-OHNP, and 8-OHNAAP were consistently detected in the drivers' urine. Concentrations of the metabolites in the taxi drivers' urine were greater than metabolite levels previously reported in non-occupationally exposed subjects; however no associations were observed between subject-specific exposures to 1-NP and urinary metabolites measured at the end of the workshift or in the next morning void. Significant autocorrelation was observed in metabolite levels in successive urine samples, from which half-lives for urinary elimination of approximately 10-12 h were estimated. These observations suggest that, in an occupational setting, urinary 1-NP metabolites may be more suitable as markers of ongoing exposure (timescales of several days) rather than indicators of acute exposure associated with single workshifts. [Description provided by NIOSH]
• Subjects:
  Automobiles Biomarkers Cohort Studies Occupational Exposure Occupational Health Particulate Matter Safety Transportation
• Keywords:
  1-nitropyrene Author Keywords: Diesel Exhaust Biomarker Cohort Studies Diesel Exhaust Drivers Exposure Assessment Occupational Exposure Particulates Transportation Workers Urinary Metabolites

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• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  170-175
• Volume:
  23
• Issue:
  2
• NIOSHTIC Number:
  nn:20054738
• Citation:
  J Expo Sci Environ Epidemiol 2013 Mar; 23(2):170-175
• Contact Point Address:
  Dr. Christopher D. Simpson, Department of Environmental and Occupational Health Sciences, Box 357234, University of Washington, Seattle, WA 98195, USA
• Email:
  simpson1@uw.edu
• CAS Registry Number:
  1-Nitropyrene (CAS RN 5522-43-0)
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73e3d1c45ce96e4047596083e76047af41cdcab4b37a76363ee67ea43f806e5d07d8737a30e3b6f17adf951f4c4fc769e67c8fc47536ff6602f8d1b0ed024c6f
• Download URL:
  https://stacks.cdc.gov/view/cdc/217174/cdc_217174_DS1.pdf
• File Type:
  [PDF - 579.34 KB ]