Lymphocytic Choriomeningitis Virus in Employees and Mice at Multipremises Feeder-Rodent Operation, United States, 2012

Knust, Barbara; Ströher, Ute; Edison, Laura; Albariño, César G.; Lovejoy, Jodi; Armeanu, Emilian; House, Jennifer; Cory, Denise; Horton, Clayton; Fowler, Kathy L.; Austin, Jessica; Poe, John; Humbaugh, Kraig E.; Guerrero, Lisa; Campbell, Shelley; Gibbons, Aridth; Reed, Zachary; Cannon, Deborah; Manning, Craig; Petersen, Brett; Metcalf, Douglas; Marsh, Bret; Nichol, Stuart T.; Rollin, Pierre E.

doi:10.3201/eid2002.130860

i

Lymphocytic Choriomeningitis Virus in Employees and Mice at Multipremises Feeder-Rodent Operation, United States, 2012

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Feb 2014
By Knust, Barbara ; Ströher, Ute ; Edison, Laura ; ...

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Emerg Infect Dis
Personal Author:

Knust, Barbara ; Ströher, Ute ; Edison, Laura ; Albariño, César G. ; Lovejoy, Jodi ; Armeanu, Emilian ; House, Jennifer ; Cory, Denise ; Horton, Clayton ; Fowler, Kathy L. ; Austin, Jessica ; Poe, John ; Humbaugh, Kraig E. ; Guerrero, Lisa ; Campbell, Shelley ; Gibbons, Aridth ; Reed, Zachary ; Cannon, Deborah ; Manning, Craig ; Petersen, Brett ; Metcalf, Douglas ; Marsh, Bret ; Nichol, Stuart T. ; Rollin, Pierre E.
Description:

We investigated the extent of lymphocytic choriomeningitis virus (LCMV) infection in employees and rodents at 3 commercial breeding facilities. Of 97 employees tested, 31 (32%) had IgM and/or IgG to LCMV, and aseptic meningitis was diagnosed in 4 employees. Of 1,820 rodents tested in 1 facility, 382 (21%) mice (Mus musculus) had detectable IgG, and 13 (0.7%) were positive by reverse transcription PCR; LCMV was isolated from 8. Rats (Rattus norvegicus) were not found to be infected. S-segment RNA sequence was similar to strains previously isolated in North America. Contact by wild mice with colony mice was the likely source for LCMV, and shipments of infected mice among facilities spread the infection. The breeding colonies were depopulated to prevent further human infections. Future outbreaks can be prevented with monitoring and management, and employees should be made aware of LCMV risks and prevention.
Subjects:

Adult Animal Husbandry Animals Antibodies, Viral Disease Outbreaks Female Humans Immunoglobulin G Immunoglobulin M Lymphocytic Choriomeningitis Male Meningitis, Aseptic Mice Occupational Exposure Phylogeny Rats Research RNA, Viral Serotyping
Source:

Emerg Infect Dis. 20(2):240-247.
Document Type:

Journal Article
Place as Subject:

Indiana ; United States
Location:

Asia ; North America
Volume:

20
Issue:

2
Collection(s):

Emerging Infectious Diseases
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urn:sha256:3284816fb3f50e56a7a58531a8db060e37ec68365c88539ddb99aa0e0ddc6e92
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https://stacks.cdc.gov/view/cdc/21715/cdc_21715_DS1.pdf
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