Lymphocytic Choriomeningitis Virus in Employees and Mice at Multipremises Feeder-Rodent Operation, United States, 2012

Knust, Barbara; Ströher, Ute; Edison, Laura; Albariño, César G.; Lovejoy, Jodi; Armeanu, Emilian; House, Jennifer; Cory, Denise; Horton, Clayton; Fowler, Kathy L.; Austin, Jessica; Poe, John; Humbaugh, Kraig E.; Guerrero, Lisa; Campbell, Shelley; Gibbons, Aridth; Reed, Zachary; Cannon, Deborah; Manning, Craig; Petersen, Brett; Metcalf, Douglas; Marsh, Bret; Nichol, Stuart T.; Rollin, Pierre E.

doi:10.3201/eid2002.130860

i

Lymphocytic Choriomeningitis Virus in Employees and Mice at Multipremises Feeder-Rodent Operation, United States, 2012

Multi-Language Supporting Files Public Domain

Feb 2014
By Knust, Barbara ; Ströher, Ute ; Edison, Laura ; Albariño, César G. ; Lovejoy, Jodi ; Armeanu, Emilian ; House, Jennifer ; Cory, Denise ; Horton, Clayton ; Fowler, Kathy L. ; Austin, Jessica ; Poe, John ; Humbaugh, Kraig E. ; Guerrero, Lisa ; Campbell, Shelley ; Gibbons, Aridth ; Reed, Zachary ; Cannon, Deborah ; Manning, Craig ; Petersen, Brett ; Metcalf, Douglas ; Marsh, Bret ; Nichol, Stuart T. ; Rollin, Pierre E.
http://dx.doi.org/10.3201/eid2002.130860

File Language:

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Knust, Barbara ; Ströher, Ute ; Edison, Laura ; Albariño, César G. ; Lovejoy, Jodi ; Armeanu, Emilian ; House, Jennifer ; Cory, Denise ; Horton, Clayton ; Fowler, Kathy L. ; Austin, Jessica ; Poe, John ; Humbaugh, Kraig E. ; Guerrero, Lisa ; Campbell, Shelley ; Gibbons, Aridth ; Reed, Zachary ; Cannon, Deborah ; Manning, Craig ; Petersen, Brett ; Metcalf, Douglas ; Marsh, Bret ; Nichol, Stuart T. ; Rollin, Pierre E.
Description:

We investigated the extent of lymphocytic choriomeningitis virus (LCMV) infection in employees and rodents at 3 commercial breeding facilities. Of 97 employees tested, 31 (32%) had IgM and/or IgG to LCMV, and aseptic meningitis was diagnosed in 4 employees. Of 1,820 rodents tested in 1 facility, 382 (21%) mice (Mus musculus) had detectable IgG, and 13 (0.7%) were positive by reverse transcription PCR; LCMV was isolated from 8. Rats (Rattus norvegicus) were not found to be infected. S-segment RNA sequence was similar to strains previously isolated in North America. Contact by wild mice with colony mice was the likely source for LCMV, and shipments of infected mice among facilities spread the infection. The breeding colonies were depopulated to prevent further human infections. Future outbreaks can be prevented with monitoring and management, and employees should be made aware of LCMV risks and prevention.
Subjects:
Source:

Emerg Infect Dis. 20(2):240-247.
Document Type:

Journal Article
Place as Subject:

Indiana ; United States
Location:

Asia ; North America
Volume:

20
Issue:

2
Download URL:

https://stacks.cdc.gov/view/cdc/21715/cdc_21715_DS1.pdf
File Type:

[PDF - 583.25 KB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:3284816fb3f50e56a7a58531a8db060e37ec68365c88539ddb99aa0e0ddc6e92

File Language:

ON THIS PAGE

Details Supporting Files

Was this page helpful?

Found an issue?

Send us an email at:

publishinghd@cdc.gov

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.